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EFFECTS OF DI‐n‐PROPYLACETATE, AN ANTICONVULSIVE COMPOUND, ON GABA METABOLISM 1
The effects on GABA metabolism of an anticonvulsant drug, di‐n‐propylacetate (DPA), were studied. Given intraperitoneally DPA increases the brain GABA content and does not change its biosynthesisExpand
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gamma-Hydroxybutyrate ligands possess antidopaminergic and neuroleptic-like activities.
The action of agonists or antagonists at the gamma-hydroxybutyrate (GHB) receptor represents a possibility to modulate dopaminergic activities in brain. In the present study, GHB and six structuralExpand
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Preferential glutamine uptake in rat brain synaptic mitochondria
Glutamine uptake has been studied in purified rat brain mitochondria of synaptic or non‐synaptic origin. It was taken up by an active saturable transport mechanism, with an affinity two‐times higherExpand
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Changes in the Uptake of GABA and Taurine During Neuronal and Glial Maturation
Abstract: The influence of the time of culture on GABA and taurine uptake was investigated in spontaneously matured cultures of glial and neuronal origins and in cultures treated with cyclicExpand
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Glutamine and glutamate transport in cultured neuronal and glial cells
The uptake of L-glutamine in neuronal and glial cultures derived from rat cerebral hemispheres was found to be mediated by a low affinity-high capacity mechanism which was concentrative in both cellExpand
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The distribution of free amino acids in the central nervous system of garden dormice during hibernation
The experiments reported here were carried out on twelve adult garden dormice. A group of six hibernating animals was killed during the first half of February; the control group was sacrificed at theExpand
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Cysteine sulfinic acid uptake in cultured neuronal and glial cells
The presence of an efficient high affinity uptake system for L-CSA has been demonstrated in cultured neuronal and glial cells of various types. In neurons and most glial cells L-CSA uptake isExpand
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High-affinity uptake of γ-aminobutyric acid in cultured glial and neuronal cells
Both glial and neuronal cells maintained in primary culture were found to accumulate [3H]GABA by an efficient “high-affinity” uptake system (apparentKm=9 μM,Vmax=0.018 and 0.584 nmol/mg/min,Expand
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A unique hydrophobic domain of rat brain globular acetylcholinesterase for binding to cell membranes
Both salt-soluble and detergent-soluble rat brain globular acetylcholinesterases (SS- and DS- AChE EC 3.1.1.7) are amphiphiles, as shown by detergent dependency of enzymatic activity and binding toExpand
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THE INFLUENCE OF NITROGEN DEPRIVATION ON FREE AMINO ACIDS IN RAT BRAIN
THE problem of the relationship between dietary input of amino acid (or proteins) and free amino acid concentration of the brain is very interesting for its functional implications. In vitro, theExpand
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