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Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008
OBJECTIVE To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock,"Expand
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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2016
Objective: To provide an update to “Surviving Sepsis Campaign Guidelines for Management of Sepsis and Septic Shock: 2012.” Design: A consensus committee of 55 international experts representing 25Expand
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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016
ObjectiveTo provide an update to “Surviving Sepsis Campaign Guidelines for Management of Sepsis and Septic Shock: 2012”.DesignA consensus committee of 55 international experts representing 25Expand
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  • Open Access
Lung stress and strain during mechanical ventilation for acute respiratory distress syndrome.
RATIONALE Lung injury caused by a ventilator results from nonphysiologic lung stress (transpulmonary pressure) and strain (inflated volume to functional residual capacity ratio). OBJECTIVES ToExpand
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Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008
To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, “Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock,” published inExpand
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  • Open Access
The American-European Consensus Conference on ARDS, part 2: Ventilatory, pharmacologic, supportive therapy, study design strategies, and issues related to recovery and remodeling. Acute respiratory
The acute respiratory distress syndrome (ARDS) continues as a contributor to the morbidity and mortality of patients in intensive care units throughout the world, imparting tremendous human andExpand
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Occult positive end-expiratory pressure in mechanically ventilated patients with airflow obstruction: the auto-PEEP effect.
Alveolar pressure can remain positive throughout the ventilatory cycle of mechanically-ventilated patients with airflow obstruction, even when positive end-expiratory pressure (PEEP) is not appliedExpand
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Recruitment and derecruitment during acute respiratory failure: a clinical study.
In a model of acute lung injury, we showed that positive end-expiratory pressure (PEEP) and tidal volume (VT) are interactive variables that determine the extent of lung recruitment, that recruitmentExpand
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Management of COVID-19 Respiratory Distress.
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Prone positioning attenuates and redistributes ventilator‐induced lung injury in dogs
Background: We previously demonstrated a markedly dependent distribution of ventilator‐induced lung injury in oleic acid‐injured supine animals ventilated with large tidal volumes and positiveExpand
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