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Neurobiological effects of a null mutation depend on genetic context: comparison between two hotfoot alleles of the delta-2 ionotropic glutamate receptor
TLDR
The results show that the genetic background must be taken into account when analyzing sensorimotor performances of mutant mice and that the Grid2(ho-4J) and Grid2 (ho-Nancy) mice approach control levels. Expand
Evidence for a multiple innervation of Purkinje cells by climbing fibers in the immature rat cerebellum.
TLDR
Results demonstrate that in the immature rat more than 50% of PCs are each innervated by at least two distinct CFs; later on, the disappearance of the supernumerary synapses between CF and PC leads, as early as day 15, to the one-to-one relationship betweenCF and PC. Expand
Specific caspase inhibitor Q‐VD‐OPh prevents neonatal stroke in P7 rat: a role for gender
TLDR
The results indicate that ischaemia activates caspases shortly after reperfusion and that the sex of the animal may strongly influences apoptotic pathways in the pathogenesis of neonatal brain injury. Expand
The orphan nuclear receptor ROR alpha is a negative regulator of the inflammatory response.
TLDR
It is demonstrated that RORalpha is expressed in human primary smooth-muscle cells and that ectopic expression of ROR alpha1 inhibits TNFalpha-induced IL-6, IL-8 and COX-2 expression in these cells, and this action of Ror alpha1 on NF-kappaB is associated with the induction of IkappaB alpha. Expand
Anatomical, physiological and biochemical studies of the cerebellum from Reeler mutant mouse.
TLDR
The reeler cerebellum offers a model to study to what extent local cellular interactions are required to achieve the planar organization of the Purkinje cell dendrites and the normal synaptic investment of these cells. Expand
Ontogenesis of olivocerebellar relationships. I. Studies by intracellular recordings of the multiple innervation of Purkinje cells by climbing fibers in the developing rat cerebellum
TLDR
It is shown that the multiple innervation of Purkinje cells by CFS was maximal on postnatal day 5 and then decreased until the innervation by a single CF was established on day 15, suggesting its existence at earlier stages. Expand
The orphan nuclear receptor RORα is a negative regulator of the inflammatory response
TLDR
It is demonstrated that RORα is expressed in human primary smooth‐muscle cells and that ectopic expression of ROR α1 inhibits TNFα‐induced IL‐6, IL‐8 and COX‐2 expression in these cells, and this action is associated with the induction of IκBα, the major inhibitory protein of the NF‐κB signalling pathway. Expand
The nuclear receptor RORα exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes
TLDR
Findings indicate that RORα is a pluripotent molecular player in constitutive and adaptive astrocyte physiology and direct control is necessary to maintain IL-6 basal level in the brain and may be a link between the neuro-supportive roles of ROR α, IL- 6, and astroCytes. Expand
NMDA Receptor Contribution to the Climbing Fiber Response in the Adult Mouse Purkinje Cell
TLDR
It is demonstrated that mature Purkinje cells express functional NMDA receptors that become detectable in CF-EPSCs at ∼21 d after birth and control the complex spike waveform and contribute to the depolarizing plateau of complex spikes and increase their number of spikelets. Expand
ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation.
TLDR
A significant increase in the number of lysosomes in Atm-/- mice in the absence of any detectable signs of neuronal degeneration or other ultrastructural anomalies suggests that ATM may be important as a cytoplasmic protein in neurons and that its absence leads to abnormalities of cytopLasmic organelles reflected as an increase in lysOSomal numbers. Expand
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