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The orphan nuclear receptor ROR alpha is a negative regulator of the inflammatory response.
It is demonstrated that RORalpha is expressed in human primary smooth-muscle cells and that ectopic expression of ROR alpha1 inhibits TNFalpha-induced IL-6, IL-8 and COX-2 expression in these cells, and this action of Ror alpha1 on NF-kappaB is associated with the induction of IkappaB alpha.
Ontogenesis of olivocerebellar relationships. I. Studies by intracellular recordings of the multiple innervation of Purkinje cells by climbing fibers in the developing rat cerebellum
It is shown that the multiple innervation of Purkinje cells by CFS was maximal on postnatal day 5 and then decreased until the innervation by a single CF was established on day 15, suggesting its existence at earlier stages.
Specific caspase inhibitor Q‐VD‐OPh prevents neonatal stroke in P7 rat: a role for gender
The results indicate that ischaemia activates caspases shortly after reperfusion and that the sex of the animal may strongly influences apoptotic pathways in the pathogenesis of neonatal brain injury.
staggerer phenotype in retinoid-related orphan receptor alpha-deficient mice.
Although the absence of RORalpha causes dramatic developmental effects in the cerebellum, it has no apparent morphological effect on thalamus, hypothalamus, and retina, and testis and skin of R ORalpha-/- mice display a normal phenotype.
Neurobiological effects of a null mutation depend on genetic context: comparison between two hotfoot alleles of the delta-2 ionotropic glutamate receptor
Anatomical, physiological and biochemical studies of the cerebellum from Reeler mutant mouse.
- J. Mariani, F. Crépel, K. Mikoshiba, J. Changeux, C. Sotelo
- BiologyPhilosophical transactions of the Royal Society…
- 2 November 1977
The reeler cerebellum offers a model to study to what extent local cellular interactions are required to achieve the planar organization of the Purkinje cell dendrites and the normal synaptic investment of these cells.
The orphan nuclear receptor RORα is a negative regulator of the inflammatory response
It is demonstrated that RORα is expressed in human primary smooth‐muscle cells and that ectopic expression of ROR α1 inhibits TNFα‐induced IL‐6, IL‐8 and COX‐2 expression in these cells, and this action is associated with the induction of IκBα, the major inhibitory protein of the NF‐κB signalling pathway.
Evidence for a multiple innervation of Purkinje cells by climbing fibers in the immature rat cerebellum.
Results demonstrate that in the immature rat more than 50% of PCs are each innervated by at least two distinct CFs; later on, the disappearance of the supernumerary synapses between CF and PC leads, as early as day 15, to the one-to-one relationship betweenCF and PC.
staggerer phenotype in retinoid-related orphan receptor α-deficient mice
Although the absence of RORα causes dramatic developmental effects in the cerebellum, it has no apparent morphological effect on thalamus, hypothalamus, and retina, and testis and skin of R ORα−/− mice display a normal phenotype.
NMDA Receptor Contribution to the Climbing Fiber Response in the Adult Mouse Purkinje Cell
- C. Piochon, T. Irinopoulou, Daniel Brusciano, Y. Bailly, J. Mariani, C. Levenes
- BiologyJournal of Neuroscience
- 3 October 2007
It is demonstrated that mature Purkinje cells express functional NMDA receptors that become detectable in CF-EPSCs at ∼21 d after birth and control the complex spike waveform and contribute to the depolarizing plateau of complex spikes and increase their number of spikelets.