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Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling.
The Wnt family of secreted glycoproteins mediate cell cell interactions during cell growth and differentiation in both embryos and adults. Canonical Wnt signalling by way of the beta-catenin pathwayExpand
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Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling
The Wnt family of secreted glycoproteins mediate cell–cell interactions during cell growth and differentiation in both embryos and adults. Canonical Wnt signalling by way of the β-catenin pathway isExpand
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Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation
DNA methylation is an epigenetic modification that is essential for gene silencing and genome stability in many organisms. Although methyltransferases that promote DNA methylation are wellExpand
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A Dnmt2-like protein mediates DNA methylation in Drosophila
The methylation status of Drosophila DNA has been discussed controversially over a long time. Recent evidence has provided strong support for the existence of 5-methylcytosine in DNA preparationsExpand
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Microcephalin and pericentrin regulate mitotic entry via centrosome-associated Chk1
Primary microcephaly, Seckel syndrome, and microcephalic osteodysplastic primordial dwarfism type II (MOPD II) are disorders exhibiting marked microcephaly, with small brain sizes reflecting reducedExpand
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The DrosDel Deletion Collection: A Drosophila Genomewide Chromosomal Deficiency Resource
We describe a second-generation deficiency kit for Drosophila melanogaster composed of molecularly mapped deletions on an isogenic background, covering ∼77% of the Release 5.1 genome. Using aExpand
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Conservation of DNA methylation in dipteran insects
DNA methylation is a central mechanism of epigenetic regulation. Whereas vertebrate DNA methylation requires at least four different DNA methyltransferases, Drosophila melanogaster only utilizes aExpand
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Cep63 recruits Cdk1 to the centrosome: implications for regulation of mitotic entry, centrosome amplification, and genome maintenance.
Centrosomes are central regulators of mitosis that are often amplified in cancer cells. Centrosomes function both as organizers of the mitotic spindle and as reaction centers to trigger activation ofExpand
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The Drosophila methyl-DNA binding protein MBD2/3 interacts with the NuRD complex via p55 and MI-2
BackgroundMethyl-DNA binding proteins help to translate epigenetic information encoded by DNA methylation into covalent histone modifications. MBD2/3 is the only candidate gene in the DrosophilaExpand
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The Drosophila MBD2/3 protein mediates interactions between the MI-2 chromatin complex and CpT/A-methylated DNA
Methyl-DNA binding proteins play an important role in epigenetic gene regulation. The Drosophila genome encodes a single protein (MBD2/3) with extended homologies to the vertebrate methyl-DNA bindingExpand
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