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Mast cell clones: a model for the analysis of cellular maturation
Cloned mouse mast cells resemble, by ultrastructure, immature mast cells observed in vivo. These mast cell clones can be grown in the absence of any other cells, facilitating direct investigations ofExpand
An integrated model of clinical reasoning: dual-process theory of cognition and metacognition.
  • J. Marcum
  • Medicine
  • Journal of evaluation in clinical practice
  • 1 October 2012
RATIONALE AND AIM Clinical reasoning is an important component for providing quality medical care. The aim of the present paper is to develop a model of clinical reasoning that integrates both theExpand
An Introductory Philosophy of Medicine: Humanizing Modern Medicine
Metaphysics.- Medical Worldviews.- Medical Causation and Realism.- Patient as Body or Person.- Disease or Illness and Health or Wellbeing.- Diagnosis and Therapeutics.- Epistemology.- MedicalExpand
Cloned bovine aortic endothelial cells synthesize anticoagulantly active heparan sulfate proteoglycan.
Cloned bovine aortic endothelial cells were cultured with [35S]Na2SO4 and proteolyzed extensively with papain. Radiolabeled heparan sulfate was isolated by DEAE-Sephacel chromatography. TheExpand
Isolation and characterization of heparan sulfate proteoglycans produced by cloned rat microvascular endothelial cells.
We have isolated heparan sulfate proteoglycans (HSPGs) from cloned rat microvascular endothelial cells using a combination of ion-exchange chromatography, affinity fractionation with antithrombin IIIExpand
Biomechanical and phenomenological models of the body, the meaning of illness and quality of care
  • J. Marcum
  • Psychology, Medicine
  • Medicine, health care, and philosophy
  • 2004
The predominant model of the body in modern western medicine is the machine. Practitioners of the biomechanical model reduce the patient to separate, individual body parts in order to diagnose andExpand
Reflections on Humanizing Biomedicine
  • J. Marcum
  • Medicine
  • Perspectives in biology and medicine
  • 2008
Although biomedicine is responsible for the “miracles” of modern medicine, paradoxically it has also led to a quality-of-care crisis in which many patients feel disenfranchised from the health-careExpand
Cancer: complexity, causation, and systems biology
Generalmente viene attribuito il successo della biologia del ventesimo secolo all’assunto che I fenomeni biologici complessi e I loro iter causali sono riconducibili a fenomeni causali elementari.Expand
The molecular genetics of breast cancer and targeted therapy
Breast cancer is a complex, molecular disease, in which a number of cellular pathways involving cell growth and proliferation, such as the MAPK, RB/E2F, P13K/AKT/mTOR, and TP53 pathways, are altered.Expand
The Virtuous Physician: The Role of Virtue in Medicine
Acknowledgments Preface 1. Medicine's crises 2. Virtue theory, ethics, and epistemology 3. Virtues and vices 4. On caring and uncaring 5. On prudent love and imprudent lovelessness 6. Medical storiesExpand