J. Marchant

Publications125
h-index35
Citations3,892
Highly Influential Citations206
Claim Author Page
Author pages are created from data sourced from our academic publisher partnerships and public sources.

Recommended Authors

  • H. Said
  • 279 Publications, 6,936 Citations
  • A. Galione
  • 261 Publications, 13,406 Citations
  • V. S. Subramanian
  • 123 Publications, 2,073 Citations
  • G. Churchill
  • 160 Publications, 6,680 Citations
  • Publications
  • Influence
Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a widespread and potent calcium-mobilizing messenger that is highly unusual in activating calcium channels located on acidic stores. However,… Expand
  • 326
  • 36
  • PDF
Role of elementary Ca2+ puffs in generating repetitive Ca2+ oscillations
Inositol (1,4,5)‐trisphosphate (IP3) liberates intracellular Ca2+ both as localized ‘puffs’ and as repetitive waves that encode information in a frequency‐dependent manner. Using video‐rate confocal… Expand
  • 195
  • 21
A continuum of InsP3‐mediated elementary Ca2+ signalling events in Xenopus oocytes
1 The elementary release events underlying inositol 1,4,5‐trisphosphate (InsP3)‐mediated calcium signalling were investigated in Xenopus oocytes by means of high‐resolution confocal linescan imaging… Expand
  • 241
  • 14
  • PDF
Cooperative activation of IP3 receptors by sequential binding of IP3 and Ca2+ safeguards against spontaneous activity
BACKGROUND Ca2+ waves allow effective delivery of intracellular Ca2+ signals to cytosolic targets. Propagation of these regenerative Ca2+ signals probably results from the activation of intracellular… Expand
  • 145
  • 9
Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition
ABSTRACT Two-pore channels (TPCs) are endolysosomal ion channels implicated in Ca2+ signalling from acidic organelles. The relevance of these ubiquitous proteins for human disease, however, is… Expand
  • 113
  • 9
  • PDF
The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation
Significance Two-pore channels (TPCs) are a recently discovered family of endolysosomal ion channels, but their regulation is controversial. By defining the TPC interactome, we provide a community… Expand
  • 75
  • 7
Re-evaluation of the Role of Calcium Homeostasis Endoplasmic Reticulum Protein (CHERP) in Cellular Calcium Signaling*
Background: Calcium homeostasis endoplasmic reticulum protein (CHERP) was originally identified as an integral endoplasmic reticulum membrane protein that regulates intracellular Ca2+ channels.… Expand
  • 70
  • 7
Activation and co‐ordination of InsP3‐mediated elementary Ca2+ events during global Ca2+ signals in Xenopus oocytes
1 The activation of elementary calcium release events (‘puffs’) and their co‐ordination to generate calcium waves was studied in Xenopus oocytes by confocal linescan imaging together with… Expand
  • 168
  • 6
  • PDF
Expression and functional contribution of hTHTR-2 in thiamin absorption in human intestine.
The aim of this study was to investigate expression and relative contribution of human thiamin transporter (hTHTR)-2 toward overall carrier-mediated thiamin uptake by human intestinal epithelial… Expand
  • 98
  • 6
  • PDF
Photoaffinity Labeling of Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Targets in Mammalian Cells*♦
Background: Nicotinic acid adenine dinucleotide phosphate (NAADP) activates two-pore channels (TPCs) to release Ca2+ from intracellular acidic Ca2+ stores. Results: A photoactivatable probe based on… Expand
  • 131
  • 5