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Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a widespread and potent calcium-mobilizing messenger that is highly unusual in activating calcium channels located on acidic stores. However,Expand
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Role of elementary Ca2+ puffs in generating repetitive Ca2+ oscillations
Inositol (1,4,5)‐trisphosphate (IP3) liberates intracellular Ca2+ both as localized ‘puffs’ and as repetitive waves that encode information in a frequency‐dependent manner. Using video‐rate confocalExpand
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A continuum of InsP3‐mediated elementary Ca2+ signalling events in Xenopus oocytes
1 The elementary release events underlying inositol 1,4,5‐trisphosphate (InsP3)‐mediated calcium signalling were investigated in Xenopus oocytes by means of high‐resolution confocal linescan imagingExpand
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Cooperative activation of IP3 receptors by sequential binding of IP3 and Ca2+ safeguards against spontaneous activity
BACKGROUND Ca2+ waves allow effective delivery of intracellular Ca2+ signals to cytosolic targets. Propagation of these regenerative Ca2+ signals probably results from the activation of intracellularExpand
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Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition
ABSTRACT Two-pore channels (TPCs) are endolysosomal ion channels implicated in Ca2+ signalling from acidic organelles. The relevance of these ubiquitous proteins for human disease, however, isExpand
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The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation
Significance Two-pore channels (TPCs) are a recently discovered family of endolysosomal ion channels, but their regulation is controversial. By defining the TPC interactome, we provide a communityExpand
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Re-evaluation of the Role of Calcium Homeostasis Endoplasmic Reticulum Protein (CHERP) in Cellular Calcium Signaling*
Background: Calcium homeostasis endoplasmic reticulum protein (CHERP) was originally identified as an integral endoplasmic reticulum membrane protein that regulates intracellular Ca2+ channels.Expand
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Activation and co‐ordination of InsP3‐mediated elementary Ca2+ events during global Ca2+ signals in Xenopus oocytes
1 The activation of elementary calcium release events (‘puffs’) and their co‐ordination to generate calcium waves was studied in Xenopus oocytes by confocal linescan imaging together withExpand
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Expression and functional contribution of hTHTR-2 in thiamin absorption in human intestine.
The aim of this study was to investigate expression and relative contribution of human thiamin transporter (hTHTR)-2 toward overall carrier-mediated thiamin uptake by human intestinal epithelialExpand
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Photoaffinity Labeling of Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Targets in Mammalian Cells*♦
Background: Nicotinic acid adenine dinucleotide phosphate (NAADP) activates two-pore channels (TPCs) to release Ca2+ from intracellular acidic Ca2+ stores. Results: A photoactivatable probe based onExpand
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