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The impact of PKR activation: from neurodegeneration to cancer
The present review highlights the current knowledge on the role of PKR in neurodegeneration and cancer, with special emphasis on its regulation and clinical implications.
Epigenetic Control of Retrotransposon Expression in Human Embryonic Stem Cells
It is suggested that distinct subsets of active L1/Alu elements are expressed in hESCs and that the degree of somatic mosaicism attributable to L1 insertions during early development may be higher than previously anticipated.
Intra-Articular Injections of Platelet-Rich Plasma versus Hyaluronic Acid in the Treatment of Osteoarthritic Knee Pain: A Randomized Clinical Trial in the Context of the Spanish National Health Care
PRP injection was proved to improve pain three months after the final infiltration and to be more effective in lower osteoarthritis grades, with results resembling those of the HA group at six months.
Functionalized Nanostructures with Application in Regenerative Medicine
The themes covered in this review include nanoparticle systems for tracking transplanted stem cells, self-assembling peptides, nanoparticles for gene delivery into stem cells and biomimetic scaffolds useful for 2D and 3D tissue cell cultures, transplantation and clinical application.
5-Fluorouracil derivatives: a patent review
The search for less toxic 5-FU derivatives, which diminish or circumvent some of its disadvantages, has allowed the development of selective antitumor prodrugs and novel methods for tissue-specific drug delivery.
Recent Progress in Gene Therapy for Ovarian Cancer
The present manuscript reviews the recent advances made in gene therapy for ovarian cancer, highlighting the latest clinical trials experience, the current challenges and future perspectives.