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Anti-tumor effect of α-pinene on human hepatoma cell lines through inducing G2/M cell cycle arrest.
Pine needle oil from crude extract of pine needles has been used as an anti-cancer agent in Traditional Chinese Medicine. The α-pinene is a natural compound isolated from pine needle oil which hasExpand
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Suppression of ClC-3 channel expression reduces migration of nasopharyngeal carcinoma cells.
Recent studies suggest that chloride (Cl-) channels regulate tumor cell migration. In this report, we have used antisense oligonucleotides specific for ClC-3, the most likely molecular candidate forExpand
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Blockage of Volume-Activated Chloride Channels Inhibits Migration of Nasopharyngeal Carcinoma Cells
Cell migration is crucial for tumor metastasis. Membrane ion channels may play a major role in tumor cell migration because the cells must undergo changes in shape and volume during migration. In theExpand
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Cisplatin Activates Volume-Sensitive Like Chloride Channels Via Purinergic Receptor Pathways in Nasopharyngeal Carcinoma Cells
Cisplatin-based concomitant chemoradiotherapy is considered as the standard treatment for locally advanced nasopharyngeal carcinoma patients. However, the curative efficacy of cisplatin-basedExpand
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Filopodial behavior is dependent on the phosphorylation state of neuronal growth cones.
Several lines of evidence suggest that phosphorylation events play an important role in transducing neurite outgrowth signals. Here we tested if such phosphorylation events altered filopodialExpand
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ClC-3 chloride channels are essential for cell proliferation and cell cycle progression in nasopharyngeal carcinoma cells.
ClC-3, a gene encoding a candidate protein for volume-activated chloride (C(-)) channels, may be involved in tumor development. Herein we report a study using an antisense "knock-down" strategy toExpand
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Chloride channel-3 promotes tumor metastasis by regulating membrane ruffling and is associated with poor survival
The chloride channel-3 (ClC-3) protein is known to be a component of Cl− channels involved in cell volume regulation or acidification of intracellular vesicles. Here, we report that ClC-3 was highlyExpand
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ClC-3 chloride channel is involved in isoprenaline-induced cardiac hypertrophy.
Isoprenaline, an activator of β-adrenergic receptor, has been found to induce cardiac hypertrophy in vivo and in vitro, but the exact mechanism is still unclear. ClC-3 is a member of the chlorideExpand
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Specific transcription of eukaryotic tRNA genes in Xenopus germinal vesicle extracts.
Cloned tRNA genes from Drosophila and from yeast have been transcribed faithfully in extracts prepared from Xenopus germinal vesicles. The newly formed RNA is composed of precursor tRNAs (of 5S RNAExpand
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Volume-activated chloride channels contribute to cell-cycle-dependent regulation of HeLa cell migration.
The activation of volume-activated chloride Cl(-) channels has been implicated to play important roles in modulating cell cycle and cell migration. The aim of this study was to determine whetherExpand
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