J. Manzanares

Publications254
h-index49
Citations7,471
Highly Influential Citations247
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Pharmacological and biochemical interactions between opioids and cannabinoids.
TLDR
The present review addresses the recent advances in the study of pharmacological interactions between opioids and cannabinoids, focusing on two aspects: antinociception and drug addiction. Expand
Impaired action of anxiolytic drugs in mice deficient in cannabinoid CB1 receptors
TLDR
The findings reveal that CB( 1) receptors are involved in the regulation of emotional responses, and play a pivotal role in the action mechanism of anxiolytics, and suggest that alterations in the functional activity of the CB(1) receptor may be related to the emergence of anxiety disorders, and may affect treatment with anxioleytics. Expand
Sex steroid influence on cannabinoid CB(1) receptor mRNA and endocannabinoid levels in the anterior pituitary gland.
TLDR
Data collectively support that expression of the CB(1) receptor gene in the anterior pituitary gland is regulated by sex steroids in both males and females and gonadal steroids appear to affect the response of this gene to chronic cannabinoid administration. Expand
Decreased Cocaine Motor Sensitization and Self-Administration in Mice Overexpressing Cannabinoid CB2 Receptors
TLDR
Results revealed that CB2r are involved in cocaine motor responses and cocaine self-administration, suggesting that this receptor could represent a promising target to develop novel treatments for cocaine addiction. Expand
Anandamide, but not 2‐arachidonoylglycerol, accumulates during in vivo neurodegeneration
TLDR
Analysis of cannabinoid CB1 receptor mRNA expression and binding capacity revealed that cortical subfields exhibited an up‐regulation of these parameters following mild concussive head trauma and exposure to NMDA receptor blockade, which may suggest that mild to moderate brain injury may trigger elevated endocannabinoid activity via concomitant increase of anandamide levels, but not 2‐AG, andCB1 receptor density. Expand
Crucial Role of CB2 Cannabinoid Receptor in the Regulation of Central Immune Responses during Neuropathic Pain
TLDR
The enhanced manifestations of neuropathic pain were replicated in irradiated wild-type mice reconstituted with bone marrow cells from CB2 knock-outs, thus demonstrating the implication of the CB2 receptor expressed in hematopoietic cells in the development of neuropathy pain at the spinal cord. Expand
Opioid and cannabinoid receptor-mediated regulation of the increase in adrenocorticotropin hormone and corticosterone plasma concentrations induced by central administration of…
TLDR
Results indicate that opiate and cannabinoid receptors are involved in the activation of the HPA axis induced by Delta(9)-THC. Expand
Cannabidiol as a Potential Treatment for Anxiety Disorders
TLDR
Overall, current evidence indicates CBD has considerable potential as a treatment for multiple anxiety disorders, with need for further study of chronic and therapeutic effects in relevant clinical populations. Expand
Depression‐resistant endophenotype in mice overexpressing cannabinoid CB2 receptors
TLDR
The role of CB2 receptors in the regulation of depressive‐like behaviours was evaluated by transgenic mice overexpressing the CB2 receptor (CB2xP) with different types of acute and chronic experimental paradigms. Expand
Differential basal proenkephalin gene expression in dorsal striatum and nucleus accumbens, and vulnerability to morphine self-administration in Fischer 344 and Lewis rats
TLDR
The results show that LEW rats responded to significantly higher breaking points than F344 rats for intravenous morphine self-administration, and basal PENK gene expression in brain regions involved in the reinforcing actions of opiates was significantly higher. Expand
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