Pharmacological and biochemical interactions between opioids and cannabinoids.
- J. Manzanares, J. Corchero, J. Romero, J. Fernández-Ruiz, J. Ramos, J. Fuentes
- BiologyTIPS - Trends in Pharmacological Sciences
- 1 July 1999
Impaired action of anxiolytic drugs in mice deficient in cannabinoid CB1 receptors
- L. Urigüen, S. Pérez-Rial, C. Ledent, T. Palomo, J. Manzanares
- Biology, PsychologyNeuropharmacology
- 1 June 2004
Cannabidiol as a Potential Treatment for Anxiety Disorders
- E. Blessing, M. Steenkamp, J. Manzanares, C. Marmar
- Psychology, MedicineNeurotherapeutics
- 4 September 2015
Overall, current evidence indicates CBD has considerable potential as a treatment for multiple anxiety disorders, with need for further study of chronic and therapeutic effects in relevant clinical populations.
Sex steroid influence on cannabinoid CB(1) receptor mRNA and endocannabinoid levels in the anterior pituitary gland.
- S. González, T. Bisogno, J. Fernández-Ruiz
- BiologyBiochemical and Biophysical Research…
- 2 April 2000
Data collectively support that expression of the CB(1) receptor gene in the anterior pituitary gland is regulated by sex steroids in both males and females and gonadal steroids appear to affect the response of this gene to chronic cannabinoid administration.
Anandamide, but not 2‐arachidonoylglycerol, accumulates during in vivo neurodegeneration
- H. H. Hansen, P. Schmid, H. Hansen
- BiologyJournal of Neurochemistry
- 1 September 2001
Analysis of cannabinoid CB1 receptor mRNA expression and binding capacity revealed that cortical subfields exhibited an up‐regulation of these parameters following mild concussive head trauma and exposure to NMDA receptor blockade, which may suggest that mild to moderate brain injury may trigger elevated endocannabinoid activity via concomitant increase of anandamide levels, but not 2‐AG, andCB1 receptor density.
Decreased Cocaine Motor Sensitization and Self-Administration in Mice Overexpressing Cannabinoid CB2 Receptors
- A. Aracil-Fernández, J. Trigo, J. Manzanares
- Biology, PsychologyNeuropsychopharmacology
- 14 March 2012
Results revealed that CB2r are involved in cocaine motor responses and cocaine self-administration, suggesting that this receptor could represent a promising target to develop novel treatments for cocaine addiction.
Opioid and cannabinoid receptor-mediated regulation of the increase in adrenocorticotropin hormone and corticosterone plasma concentrations induced by central administration of…
- J. Manzanares, J. Corchero, J. Fuentes
- Biology, MedicineBrain Research
- 21 August 1999
Depression‐resistant endophenotype in mice overexpressing cannabinoid CB2 receptors
- M. García-Gutiérrez, J. M. Pérez-Ortiz, A. Gutiérrez-Adán, J. Manzanares
- Medicine, BiologyBritish Journal of Pharmacology
- 1 August 2010
The role of CB2 receptors in the regulation of depressive‐like behaviours was evaluated by transgenic mice overexpressing the CB2 receptor (CB2xP) with different types of acute and chronic experimental paradigms.
Deletion of CB2 Cannabinoid Receptor Induces Schizophrenia-Related Behaviors in Mice
- A. Ortega-Álvaro, A. Aracil-Fernández, M. García-Gutiérrez, F. Navarrete, J. Manzanares
- Psychology, BiologyNeuropsychopharmacology
- 23 March 2011
The results suggest that deletion of CB2r has a relation with schizophrenia-like behaviors and Pharmacological manipulation ofCB2r may merit further study as a potential therapeutic target for the treatment of schizophrenia-related disorders.
Crucial Role of CB2 Cannabinoid Receptor in the Regulation of Central Immune Responses during Neuropathic Pain
- I. Rácz, X. Nadal, R. Maldonado
- Biology, MedicineJournal of Neuroscience
- 12 November 2008
The enhanced manifestations of neuropathic pain were replicated in irradiated wild-type mice reconstituted with bone marrow cells from CB2 knock-outs, thus demonstrating the implication of the CB2 receptor expressed in hematopoietic cells in the development of neuropathy pain at the spinal cord.
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