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Functional definition and characterization of acute traumatic coagulopathy
Objective:To identify an appropriate diagnostic tool for the early diagnosis of acute traumatic coagulopathy and validate this modality through prediction of transfusion requirements in traumaExpand
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Circulating histones are mediators of trauma-associated lung injury.
RATIONALE Acute lung injury is a common complication after severe trauma, which predisposes patients to multiple organ failure. This syndrome largely accounts for the late mortality that arises andExpand
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The incidence and magnitude of fibrinolytic activation in trauma patients
Summary.  Background: Trauma is a global disease, with over 2.5 million deaths annually from hemorrhage and coagulopathy. Overt hyperfibrinolysis is rare in trauma, and is associated with massiveExpand
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Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study
Summary Background The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to beExpand
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Hemostatic effects of fresh frozen plasma may be maximal at red cell ratios of 1:2.
BACKGROUND Damage control resuscitation targets acute traumatic coagulopathy with the early administration of high-dose fresh frozen plasma (FFP). FFP is administered empirically and as a ratio withExpand
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Trauma alarmins as activators of damage‐induced inflammation
A systemic inflammatory response syndrome (SIRS) is frequently observed after traumatic injury. The response is sterile and the activating stimulus is tissue damage. Endogenous molecules, calledExpand
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Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study
Background Severe trauma induces a widespread response of the immune system. This “genomic storm” can lead to poor outcomes, including Multiple Organ Dysfunction Syndrome (MODS). MODS carries a highExpand
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Early changes within the lymphocyte population are associated with the development of multiple organ dysfunction syndrome in trauma patients
BackgroundEarly survival following severe injury has been improved with refined resuscitation strategies. Multiple organ dysfunction syndrome (MODS) is common among this fragile group of patientsExpand
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Trauma-Induced Secondary Cardiac Injury Is Associated With Hyperacute Elevations in Inflammatory Cytokines
Introduction Clinical evidence supports the existence of a trauma-induced secondary cardiac injury. Experimental research suggests inflammation as a possible mechanism. The study aimed to determineExpand
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Clinical and biomarker profile of trauma‐induced secondary cardiac injury
Secondary cardiac injury has been demonstrated in critical illness and is associated with worse outcomes. The aim of this study was to establish the existence of trauma‐induced secondary cardiacExpand
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