• Publications
  • Influence
The Columbia-Suicide Severity Rating Scale: initial validity and internal consistency findings from three multisite studies with adolescents and adults.
Findings suggest that the Columbia-Suicide Severity Rating Scale is suitable for assessment of suicidal ideation and behavior in clinical and research settings.
Suicide prevention strategies: a systematic review.
Physician education in depression recognition and treatment and restricting access to lethal methods reduce suicide rates, and other interventions need more evidence of efficacy.
Toward a clinical model of suicidal behavior in psychiatric patients.
A stress-diathesis model is proposed in which the risk for suicidal acts is determined not merely by a psychiatric illness but also by a diathesis, reflected in tendencies to experience more suicidal ideation and to be more impulsive and, therefore, more likely to act on suicidal feelings.
Neurobiology of suicidal behaviour
  • J. Mann
  • Medicine, Psychology
    Nature Reviews Neuroscience
  • 1 October 2003
A proposed stress–diathesis model is described in clinical and neurobiological terms, and correlates of the diathesis for suicidal acts point to the involvement of the serotonergic and noradrenergic systems, and the ventromedial prefrontal cortex.
Increased baseline occupancy of D2 receptors by dopamine in schizophrenia.
Elevated synaptic dopamine was predictive of good treatment response of positive symptoms to antipsychotic drugs and increased stimulation of D(2) receptors by dopamine in schizophrenia, consistent with increased phasic activity of dopaminergic neurons.
A Current Perspective of Suicide and Attempted Suicide
  • J. Mann
  • Medicine
    Annals of Internal Medicine
  • 19 February 2002
The neurobiological correlates of the stressors and the diathesis for suicidal behavior are described and the factors that determined inclusion in this review were superiority of research design, quality of psychometrics, and adequate representation of major points of view.
Lrp5 Controls Bone Formation by Inhibiting Serotonin Synthesis in the Duodenum
It is shown here that Lrp5 inhibits expression of Tph1, the rate-limiting biosynthetic enzyme for serotonin in enterochromaffin cells of the duodenum, and decreasing serotonin blood levels normalizes bone formation and bone mass in L rp5-deficient mice.
Continuation pharmacotherapy in the prevention of relapse following electroconvulsive therapy: a randomized controlled trial.
It is indicated that without active treatment, virtually all remitted patients relapse within 6 months of stopping ECT, and the combination of nortriptyline and lithium is more effective, but the relapse rate is still high, particularly during the first month of continuation therapy.
Antidepressants increase neural progenitor cells in the human hippocampus
The increase of NPCs and dividing cells in MDDT was localized to the rostral DG, and whether this finding is critical or necessary for the antidepressants effect remains to be determined.
Family genetic studies, suicide, and suicidal behavior
  • D. Brent, J. Mann
  • Medicine, Biology
    American journal of medical genetics. Part C…
  • 15 February 2005
A family history of suicidal behavior is associated with suicidal behavior in the proband, even after adjusting for presence of psychiatric disorders in the Proband and family, indicating transmission of attempt that is distinct from family transmission of psychiatric disorder.