J. Mandl

Publications165
h-index34
Citations3,609
Highly Influential Citations105
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Vitamin C: update on physiology and pharmacology
Although ascorbic acid is an important water‐soluble antioxidant and enzyme cofactor in plants and animals, humans and some other species do not synthesize ascorbate due to the lack of the enzyme… Expand
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Ascorbate metabolism and its regulation in animals.
This article provides a comprehensive review on ascorbate metabolism in animal cells, especially in hepatocytes. The authors deal with the synthesis and the breakdown of ascorbate as a part of the… Expand
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Preferential Transport of Glutathione versusGlutathione Disulfide in Rat Liver Microsomal Vesicles*
A bi-directional, saturable transport of glutathione (GSH) was found in rat liver microsomal vesicles. GSH transport could be inhibited by the anion transport blockers flufenamic acid and… Expand
  • 109
  • 8
On the role of 4-hydroxynonenal in health and disease.
Polyunsaturated fatty acids are susceptible to peroxidation and they yield various degradation products, including the main α,β-unsaturated hydroxyalkenal, 4-hydroxy-2,3-trans-nonenal (HNE) in… Expand
  • 113
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The glucose-6-phosphate transporter-hexose-6-phosphate dehydrogenase-11beta-hydroxysteroid dehydrogenase type 1 system of the adipose tissue.
11beta-hydroxysteroid dehydrogenase type 1, expressed mainly in the endoplasmic reticulum of adipocytes and hepatocytes, plays an important role in the prereceptorial activation of glucocorticoids.… Expand
  • 42
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Hexose-6-phosphate dehydrogenase in the endoplasmic reticulum
Abstract Hexose-6-phosphate dehydrogenase (H6PD) is a luminal enzyme of the endoplasmic reticulum that is distinguished from cytosolic glucose-6-phosphate dehydrogenase by several features. H6PD… Expand
  • 42
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BGP-15 inhibits caspase-independent programmed cell death in acetaminophen-induced liver injury.
It has been recently shown that acute acetaminophen toxicity results in endoplasmic reticulum redox stress and an increase in cells with apoptotic phenotype in liver. Since activation of effector… Expand
  • 49
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Dehydroascorbate and Ascorbate Transport in Rat Liver Microsomal Vesicles*
Ascorbate and dehydroascorbate transport was investigated in rat liver microsomal vesicles using radiolabeled compounds and a rapid filtration method. The uptake of both compounds was time- and… Expand
  • 78
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Acetaminophen induces ER dependent signaling in mouse liver.
Role of endoplasmic reticulum (ER) in liver injury by acetaminophen (AAP) was studied in vivo in mice. Sublethal dose of AAP resulted in a decrease in microsomal total glutathione and in the… Expand
  • 72
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Natural mutations lead to enhanced proteasomal degradation of human Ncb5or, a novel flavoheme reductase.
NADH cytochrome b5 oxidoreductase (Ncb5or) protects β-cells against oxidative stress and lipotoxicity. The predominant phenotype of lean Ncb5or-null mouse is insulin-dependent diabetes due to β-cell… Expand
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