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CDK1 stabilizes HIF-1α via direct phosphorylation of Ser668 to promote tumor growth
Hypoxia-inducible factor 1 (HIF-1) is a major mediator of tumor physiology, and its activation is correlated with tumor progression, metastasis, and therapeutic resistance. HIF-1 is activated in a… Expand
Current Role of Radiation Therapy for Multiple Myeloma
Background: Radiation therapy (RT) is a treatment modality traditionally used in patients with multiple myeloma (MM), but little is known regarding the role and effectiveness of RT in the era of… Expand
Correlating Metabolic Activity with Cellular Proliferation in Follicular Lymphomas
PurposeThe aim of this study was to correlate metabolic behavior of follicular lymphoma with proliferative index (Ki67).Materials and MethodsPre-treatment 2-deoxy-2-[F-18]fluoro-d-glucose positron… Expand
Cutaneous involvement in multiple myeloma (MM): A case series with clinicopathologic correlation.
- J. Malysz, G. Talamo, +5 authors C. Chung
- Journal of the American Academy of Dermatology
- 1 May 2016
BACKGROUND Disease-specific skin lesions are rare in patients with multiple myeloma (MM). OBJECTIVE We sought to further characterize the clinical and pathologic features of patients with cutaneous… Expand
Perceived levels of pain associated with bone marrow aspirates and biopsies.
BACKGROUND Little is known about the degree of pain experienced by patients undergoing a bone marrow aspiration and biopsy (BMAB). OBJECTIVE To evaluate the effectiveness of several strategies… Expand
Correlation of JAK2 V617F mutant allele quantitation with clinical presentation and type of chronic myeloproliferative neoplasm.
Activating JAK2 V617F mutation is present in many patients with chronic myeloproliferative neoplasms. We evaluated, retrospectively, clinical and laboratory data from 70 patients with BCR-ABL1… Expand
A case of vasculopathy of unknown etiology associated with fatal hydrops fetalis and review of the literature on intimomedial mucoid degeneration.
- Michael P Zaleski, Youngmin Chu, +7 authors K. Millington
- Cardiovascular pathology : the official journal…
- 1 March 2018
Non-immune hydrops fetalis (NIHF) has a high mortality rate . Many etiologies of NIHF have been identified, including cardiovascular abnormalities, severe anemia, and genetic defects. In patients… Expand
Orbital Involvement in Extranodal Natural Killer T Cell Lymphoma: An Atypical Case Presentation and Review of The Literature
Purpose: To report a rare case of extranodal NK/T cell lymphoma (NKTL) and to compare its features with those cases previously reported. Design: Case report, observational and literature review.… Expand
Sangivamycin-like Molecule 6 Exhibits Potent Anti-Multiple Myeloma Activity through Inhibition of Cyclin-Dependent Kinase-9
- N. Dolloff, J. Allen, +5 authors W. El-Deiry
- Medicine, Biology
- Molecular Cancer Therapeutics
- 10 September 2012
Despite significant treatment advances over the past decade, multiple myeloma (MM) remains largely incurable. In this study we found that MM cells were remarkably sensitive to the death-inducing… Expand
Nodular fasciitis in the axillary tail of the breast.
Nodular fasciitis is a benign proliferation of myofibroblasts which presents clinically as a rapidly growing mass with nonspecific features on imaging and high cellular activity on histopathology.… Expand