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Analgesic activity of substance P following intracerebral administration in rats.
Abstract Substance P was found to be a potent, long-lasting analgesic in the tail flick test in rats following intracerebral administration, via chronically indwelling cannulae, into the midbrain… Expand
The pharmacology of isolation-induced aggressive behavior in mice.
- J. Malick
- Current developments in psychopharmacology
This review attempts to summarize the literature on the effects of drugs on isolation-induced aggression in mice. In spite of the fact that each investigator that was surveyed utilized different… Expand
Quipazine-induced head-twitch in mice
- J. Malick, Eleanor Doren, A. Barnett
- Psychology, Medicine
- Pharmacology Biochemistry and Behavior
- 1 March 1977
Quipazine has been reported to be a direct serotonin receptor agonist. In this laboratory, quipazine produced head-twitch in mice similar to that produced by the serotonin precursor,… Expand
The evaluation of anti-parkinson drugs on reserpine-induced rigidity in rats.
- J. M. Goldstein, A. Barnett, J. Malick
- Chemistry, Medicine
- European journal of pharmacology
- 1 August 1975
The effect of anti-parkinson drugs on reserpine-induced rigidity was examined using a technique which measured rigidity by hind limb palpation. Centrally acting dopaminergic and anti-cholinergic… Expand
Seroquel: electrophysiological profile of a potential atypical antipsychotic
Extracellular single unit recording techniques were employed to compare the effects of seroquel with the reference antipsychotic (AP) agents clozapine and haloperidol in electrophysiological tests… Expand
Novel non-benzodiazepine anxiolytics
Several new non-benzodiazepine anxiolytics are reported. These include tracazolate, zopiclone, CL218,872, CGS9896, buspirone, MK-801 and fenobam. A comparison of anticonflict effects and propensity… Expand
Differential antagonism of the anticonflict effects of typical and atypical anxiolytics.
Selected benzodiazepine and non-benzodiazepine agents were studied alone or in the presence of benzodiazepine antagonists in the shock-induced suppression of drinking (SSD) procedure in rats. The… Expand
ICI 204,636, a novel, atypical antipsychotic: early indication of safety and efficacy in patients with chronic and subchronic schizophrenia.
- L. Fabre, L. Arvanitis, J. Pultz, V. Jones, J. Malick, V. Slotnick
- Clinical therapeutics
- 1 May 1995
We evaluated the effects of ICI 204,636 in 12 hospitalized patients with schizophrenia in a double-blind, placebo-controlled, parallel-group, rising-dose study. Patients met the Diagnostic and… Expand
Drug Discovery and Development
The process of drug discovery involves a melding of many disciplines and interests, transcending the relatively simple process of identifying an active compound in the test tube. The discovery of a… Expand
Effects of isoproterenol and chlordiazepoxide on drinking and conflict behaviors in rats
Isoproterenol, a beta-adrenergic agents, induced drinking in water-satiated rats. Isopropeternol exhibited significant anti-conflict activity on water-deprived rats in the Shock-induced Suppression… Expand