• Publications
  • Influence
Analgesic activity of substance P following intracerebral administration in rats.
Abstract Substance P was found to be a potent, long-lasting analgesic in the tail flick test in rats following intracerebral administration, via chronically indwelling cannulae, into the midbrainExpand
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The pharmacology of isolation-induced aggressive behavior in mice.
  • J. Malick
  • Medicine
  • Current developments in psychopharmacology
  • 1979
This review attempts to summarize the literature on the effects of drugs on isolation-induced aggression in mice. In spite of the fact that each investigator that was surveyed utilized differentExpand
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Quipazine-induced head-twitch in mice
Quipazine has been reported to be a direct serotonin receptor agonist. In this laboratory, quipazine produced head-twitch in mice similar to that produced by the serotonin precursor,Expand
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The evaluation of anti-parkinson drugs on reserpine-induced rigidity in rats.
The effect of anti-parkinson drugs on reserpine-induced rigidity was examined using a technique which measured rigidity by hind limb palpation. Centrally acting dopaminergic and anti-cholinergicExpand
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Seroquel: electrophysiological profile of a potential atypical antipsychotic
Extracellular single unit recording techniques were employed to compare the effects of seroquel with the reference antipsychotic (AP) agents clozapine and haloperidol in electrophysiological testsExpand
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Novel non-benzodiazepine anxiolytics
Several new non-benzodiazepine anxiolytics are reported. These include tracazolate, zopiclone, CL218,872, CGS9896, buspirone, MK-801 and fenobam. A comparison of anticonflict effects and propensityExpand
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Differential antagonism of the anticonflict effects of typical and atypical anxiolytics.
Selected benzodiazepine and non-benzodiazepine agents were studied alone or in the presence of benzodiazepine antagonists in the shock-induced suppression of drinking (SSD) procedure in rats. TheExpand
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ICI 204,636, a novel, atypical antipsychotic: early indication of safety and efficacy in patients with chronic and subchronic schizophrenia.
We evaluated the effects of ICI 204,636 in 12 hospitalized patients with schizophrenia in a double-blind, placebo-controlled, parallel-group, rising-dose study. Patients met the Diagnostic andExpand
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Drug Discovery and Development
The process of drug discovery involves a melding of many disciplines and interests, transcending the relatively simple process of identifying an active compound in the test tube. The discovery of aExpand
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Effects of isoproterenol and chlordiazepoxide on drinking and conflict behaviors in rats
  • J. Patel, J. Malick
  • Psychology, Medicine
  • Pharmacology Biochemistry and Behavior
  • 1 May 1980
Isoproterenol, a beta-adrenergic agents, induced drinking in water-satiated rats. Isopropeternol exhibited significant anti-conflict activity on water-deprived rats in the Shock-induced SuppressionExpand
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