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Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus
- J. Malberg, A. Eisch, E. Nestler, R. Duman
- Biology, PsychologyThe Journal of Neuroscience
- 15 December 2000
Investigation of the effect of antidepressants on hippocampal neurogenesis in the adult rat using the thymidine analog bromodeoxyuridine (BrdU) as a marker for dividing cells demonstrates that chronic antidepressant treatment significantly increases the number of BrdU-labeled cells in the dentate gyrus and hilus of the hippocampus.
Cell Proliferation in Adult Hippocampus is Decreased by Inescapable Stress: Reversal by Fluoxetine Treatment
It is reported that exposure to avoidance testing, regardless of pre-exposure to IS, decreases cell proliferation in the hippocampus, extending previous studies demonstrating downregulation of neurogenesis by exposure to acute stressors.
Regulation of Neurogenesis in Adult Mouse Hippocampus by cAMP and the cAMP Response Element-Binding Protein
The results suggest that the cAMP–CREB cascade could contribute to the actions of neurotransmitters and neurotrophic factors on adult neurogenesis.
Small Changes in Ambient Temperature Cause Large Changes in 3,4-Methylenedioxymethamphetamine (MDMA)-Induced Serotonin Neurotoxicity and Core Body Temperature in the Rat
The amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA) is a drug of abuse and has been shown to be neurotoxic to 5-HT terminals in many species. MDMA-engendered neurotoxicity has been…
Neural plasticity to stress and antidepressant treatment
Neuronal plasticity and survival in mood disorders
Regulation of Adult Neurogenesis by Antidepressant Treatment
Anxiolytic-like activity of oxytocin in male mice: behavioral and autonomic evidence, therapeutic implications
The results of this study provide specific behavioral and autonomic evidence of anxiolytic-like effects for oxytocin in males and suggest the potential utility of OTR agonism as a therapeutically relevant mechanism of action for novel anxIOlytics in both sexes.
Co-administration of MDMA with drugs that protect against MDMA neurotoxicity produces different effects on body temperature in the rat.
A decrease in CORE TEMP is suggested to be a mechanisms of protection against MDMA neurotoxicity by some drugs but that there is also a mechanism of protection that is independent of a change in body temperature.
Localization of Phosphorylated cAMP Response Element-Binding Protein in Immature Neurons of Adult Hippocampus
Findings indicate that the cAMP–CREB pathway regulates the survival, and possibly the differentiation and function, of newborn neurons.