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Development of a Highly Specific RecombinantToxocara canis Second-Stage Larva Excretory-Secretory Antigen for Immunodiagnosis of Human Toxocariasis
The recombinant antigen is highly specific for toxocariasis and may provide more reliable diagnostic results than other methods and is supported by experiments with animals infected with Ascaris and hookworm.
In vitro determination of the effect of Andrographis paniculata extracts and andrographolide on human hepatic cytochrome P450 activities
Data presented in this study suggest that AP extracts have the potential to inhibit CYP isoforms in vitro, there was, however, variation in the potency of inhibition depending on the extracts and the isoforms investigated.
Significant Reduction of Brain Cysts Caused by Toxoplasma gondii after Treatment with Spiramycin Coadministered with Metronidazole in a Mouse Model of Chronic Toxoplasmosis
- W. K. Chew, I. Segarra, S. Ambu, J. Mak
- Biology, MedicineAntimicrobial Agents and Chemotherapy
- 23 January 2012
Enhanced spiramycin brain exposure after coadministration reduced brain cysts 15-fold and Spiramycin reduced in vitro reactivation, causing a significant reduction of T. gondii brain Cysts, with potential clinical translatability for chronic toxoplasmosis treatment.
In vitro antimalarial activity of quassinoids from Eurycoma longifolia against Malaysian chloroquine-resistant Plasmodium falciparum isolates.
Three quassinoids from the roots of Eurycoma longifolia Jack were evaluated for antimalarial activity against nine Plasmodium falciparum isolates obtained from patients infected with…
Isolation and characterization of Acanthamoeba spp. from air-conditioners in Kuala Lumpur, Malaysia
Blastocystis in animal handlers
The in vitro culture method used in the study detected that people who work closely with animals do stand at risk of acquiring Blastocystis infection.
Epidemiology of lymphatic filariasis.
- J. Mak
- MedicineCiba Foundation symposium
- 28 September 2007
A rational approach to control of filariasis should consider ecological, socioeconomic and behavioural factors and, where feasible, integrate control programmes into the delivery system for primary health care.
In vitro modulatory effects of Andrographis paniculata, Centella asiatica and Orthosiphon stamineus on cytochrome P450 2C19 (CYP2C19).
Drinking water is a significant predictor of Blastocystis infection among rural Malaysian primary schoolchildren
- A. M. Abdulsalam, I. Ithoi, H. Al-Mekhlafi, Abdulhamid Ahmed, J. Surin, J. Mak
- 23 March 2012
Blastocystis is prevalent among rural children and the important factors that determine the infection were the sources of drinking water and mothers' educational level.
Relationship between hepatitis C virus infection and type 2 diabetes mellitus: meta-analysis.
The findings support the association between hepatitis C infection and type 2 diabetes mellitus and suggest that hepatitis C-infected patients had a higher risk of developing type 1 diabetes compared with uninfected controls.