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Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site.
- E. Graf, J. Mahoney, R. Bryant, J. Eaton
- Chemistry, Medicine
- The Journal of biological chemistry
- 25 March 1984
The catalysis by iron of the formation of reactive oxygen species in biological systems has been well documented. In this present study, we have investigated the hypothesis that iron-catalyzed… Expand
Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells
- B. Beutler, J. Mahoney, N. Le Trang, P. Pekala, A. Cerami
- Biology, Medicine
- The Journal of experimental medicine
- 1 May 1985
Previous studies have indicated that endotoxin and other bacterial and protozoal products can stimulate macrophages to produce a factor that can suppress the activity of the enzyme lipoprotein lipase… Expand
Thiocyanate is the major substrate for eosinophil peroxidase in physiologic fluids. Implications for cytotoxicity.
The potent cytotoxic capacity of eosinophils for parasites and host tissue has in part been attributed to the catalytic action of eosinophil peroxidase (EPO), which preferentially oxidizes Br- to the… Expand
Bacterial glutathione: a sacrificial defense against chlorine compounds.
Aerobic organisms possess a number of often overlapping and well-characterized defenses against common oxidants such as superoxide and hydrogen peroxide. However, much less is known of mechanisms of… Expand
Role of Alpha‐Tocopherol, Ascorbic Acid, Citric Acidand EDTA as Oxidants in Model Systems
The effects of four widely employed “antioxidants” on iron-mediated hydroxyl radical formation and lipid peroxidation were studied in aqueous model systems. Iron and copper served as catalysts for… Expand
Contrasting effects of hypochlorous acid and hydrogen peroxide on endothelial permeability: prevention with cAMP drugs.
- L. Ochoa, G. Waypa, J. Mahoney, L. Rodríguez, F. Minnear
- American journal of respiratory and critical care…
- 1 October 1997
Activated polymorphonuclear leukocytes generate a cascade of reduced oxygen metabolites. In addition to their antimicrobial role, hydrogen peroxide (H2O2) and hypochlorous acid (HOCl) function as… Expand
Enhanced high energy phosphate recovery with ribose infusion after global myocardial ischemia in a canine model.
High energy phosphate levels are depressed following global ischemia and require several days to completely recover. Short-term methods to enhance ATP recovery have included infusion of ATP… Expand
A spectrophotometric assay for chlorine-containing compounds.
Determinations of hypochlorous acid and chloramine compounds are important in a number of areas. Several techniques are now available for such analyses, but most require unstable reagents and/or… Expand
Racial differences in hypertension-associated red cell sodium permeability
The prevalence and severity of essential hypertension varies greatly among human populations. Some of this variation is undoubtedly due to differences in dietary Na+ levels1. However, even within… Expand
Haptoglobin: a natural bacteriostat.
The combination of bacteria and blood in a wound can have lethal consequences, probably because hemoglobin iron supports prolific bacterial growth. Rats inoculated intraperitoneally with pathogenic… Expand