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Total synthesis of (+/-)-mersicarpine.
The first total synthesis of the indole alkaloid mersicarpine is reported. Key steps include a beta-dicarbonyl radical cyclization, as well as an oxidation of the benzopyrrole moiety to establish theExpand
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Expanding the scope of Mn(OAc)3-mediated cyclizations: synthesis of the tetracyclic core of tronocarpine.
Pyrroles, indoles, and surprisingly, indolines, when equipped with a pendant malonyl group on the nitrogen atom, were effective substrates in a Mn(III)-mediated oxidative cyclization reaction,Expand
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Directed remote aromatic metalations: mechanisms and driving forces.
Directed remote aromatic metalations are useful synthetic transformations allowing for rapid regioselective access to elaborate highly substituted carbocyclic aromatic and heteroaromatic systems.Expand
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Evaluation of synthetic coumarins for antiausterity cytotoxicity against pancreatic cancers.
A series of functionalized coumarins were synthesized and evaluated for their capacity to inhibit the resistance to starvation of pancreatic cancer cells. This form of cytotoxicity, termedExpand
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Mechanism of Action of an EPAC1-Selective Competitive Partial Agonist.
The exchange protein activated by cAMP (EPAC) is a promising drug target for a wide disease range, from neurodegeneration and infections to cancer and cardiovascular conditions. A novel partialExpand
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Aryl methyl sulfides via SNAr using DMSO as the source of the thiomethyl moiety
Abstract A unique synthesis of aryl methyl sulfides is reported proceeding via reduction of dimethylsulfoxide to dimethylsulfide at elevated temperature in the presence of Hunig’s base followed byExpand
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Synthesis of the western half of the lolicines and lolitrems.
[reaction: see text] The synthesis of the highly substituted indole portion of the complex tremorgenic natural products lolicine A and B is presented. The Diels-Alder reaction of a quinone monoimineExpand
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Biaryl Ketones by Suzuki–Miyaura Cross-Coupling of Organotrifluoroborates and Acyl Chlorides
A procedure for the synthesis of biaryl ketones by a palladium-catalyzed Suzuki–Miyaura cross-coupling reaction between phenyltrifluoroborates and benzoyl chlorides is described.Expand
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Dehydroaromatization with V2O5
Vanadium pentoxide is evaluated as a dehydroaromatization reagent. Tetrahydrocarbazole is readily aromatized by V2O5 in refluxing acetic acid under both stoichiometric and catalytic conditions.Expand
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Combined Pd/C and Montmorillonite Catalysis for One-Pot Synthesis of Benzimidazoles.
A series of nineteen benzimidazoles are prepared from ortho-nitroanilines via one-pot transfer hydrogenation, condensation, and dehydrogenation enabled by the concurrent use of two heterogeneousExpand
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