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Single-Cell Characterization of Retrograde Signaling by Brain-Derived Neurotrophic Factor
Brain-derived neurotrophic factor (BDNF) is a key regulator of hippocampal synaptic plasticity in the developing and adult nervous system. It can be released from pyramidal neuron dendrites in anExpand
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Role of Calcium and Calpain in the Downregulation of Voltage‐Gated Sodium Channel Expression by the Pyrethroid Pesticide Deltamethrin
Voltage‐gated sodium channels (Nav) are essential for initiation and propagation of action potentials. Previous in vitro studies reported that exposure to the Nav toxins veratridine and α scorpionExpand
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Developmental pyrethroid exposure causes long‐term decreases of neuronal sodium channel expression
HIGHLIGHTSDevelopmental deltamethrin exposure causes region‐specific changes in sodium channel subunit expression.Developmental deltamethrin exposure causes decreased BDNF expression.Deficits in BDNFExpand
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Channelopathies: summary of the hot topic keynotes session.
The "Hot Topic Keynotes: Channelopathies" session of the 26th International Neurotoxicology Conference brought together toxicologists studying interactions of environmental toxicants with ionExpand
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Skin sensitization in silico protocol.
The assessment of skin sensitization has evolved over the past few years to include in vitro assessments of key events along the adverse outcome pathway and opportunistically capitalize on theExpand
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(Im)Perfectly Safe
TLDR
Paper will discuss chemical substances sometimes found in electronic products that get bad press, but for which there is not always sound toxicological science that should require bans at levels used. Expand
Selective Vulnerability in the Nervous System
There are a number of factors that give rise to the selective vulnerability of the nervous system to toxic insult. This chapter attempts to give an overview to allow the reader to better understandExpand