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Deleted in Malignant Brain Tumors 1 is a versatile mucin-like molecule likely to play a differential role in digestive tract cancer.
Deleted in Malignant Brain Tumors 1 (DMBT1) has been proposed as a candidate tumor suppressor gene for brain, lung, and digestive tract cancer. In particular, alterations of the gene and/or a loss ofExpand
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Polymersome-mediated delivery of combination anticancer therapy to head and neck cancer cells: 2D and 3D in vitro evaluation.
Polymersomes have the potential to encapsulate and deliver chemotherapeutic drugs into tumor cells, reducing off-target toxicity that often compromises anticancer treatment. Here, we assess theExpand
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LRP-1-mediated intracellular antibody delivery to the Central Nervous System
The blood-brain barrier (BBB) is by far the most important target in developing new approaches to improve delivery of drugs and diagnostic tools into the Central Nervous System (CNS). Here we reportExpand
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Quantitative evaluation of mechanosensing of cells on dynamically tunable hydrogels.
Thin hydrogel films based on an ABA triblock copolymer gelator [where A is pH-sensitive poly(2-(diisopropylamino)ethyl methacrylate) (PDPA) and B is biocompatible poly(2-(methacryloyloxy)ethylExpand
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Encapsulation of biomacromolecules within polymersomes by electroporation.
Biological macromolecules can be encapsulated into preformed polymersomes by controlled temporary destabilization of the vesicle membrane. The morphology and the size of the polymersome are unchangedExpand
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Diffusion Studies of Nanometer Polymersomes Across Tissue Engineered Human Oral Mucosa
PurposeTo measure the diffusion of nanometer polymersomes through tissue engineered human oral mucosa.MethodsIn vitro models of full thickness tissue engineered oral mucosa (TEOM) were used to assessExpand
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Mechanistic insights for block copolymer morphologies: how do worms form vesicles?
Amphiphilic diblock copolymers composed of two covalently linked, chemically distinct chains can be considered to be biological mimics of cell membrane-forming lipid molecules, but with typicallyExpand
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Efficient encapsulation of plasmid DNA in pH-sensitive PMPC-PDPA polymersomes: study of the effect of PDPA block length on copolymer-DNA binding affinity.
We report the self-assembly of a series of amphiphilic diblock copolymers comprising a biocompatible, hydrophilic block, poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) and a pH-sensitiveExpand
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Enhanced drug delivery to melanoma cells using PMPC-PDPA polymersomes.
We present the efficient and stable encapsulation of doxorubicin within pH sensitive polymeric vesicles (polymersomes) for intracellular and nuclear delivery to melanoma cells. We demonstrate thatExpand
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