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Tissue factor promotes melanoma metastasis by a pathway independent of blood coagulation.
TLDR
A murine model of human melanoma metastasis was used and results indicate that the cytoplasmic domain of TF is important for the metastatic effect, suggesting that the TF could transduce a melanoma cell signal that promotes metastasis. Expand
Mutations in genetic variants of human serum albumin found in Italy.
TLDR
The ability to distinguish so many alloalbumin types by electrophoresis at several pH values indicates that similar substitutions at different sites produce variants with different electrophoretic mobilities. Expand
Alloalbuminemia in Sweden: structural study and phenotypic distribution of nine albumin variants.
TLDR
The high frequency and relatively uniform geographic distribution of the Arg-2----Cys mutation suggest that it may have occurred in a founder individual many generation ago in Sweden. Expand
Hypermutability of CpG dinucleotides in the propeptide-encoding sequence of the human albumin gene.
An electrophoretically slow albumin variant was detected with a phenotype frequency of about 1:1000 in Sweden and was also found in a family of Scottish descent from Kaikoura, New Zealand, and inExpand
Analbuminemia: three cases resulting from different point mutations in the albumin gene.
TLDR
The paradox is that analbuminemia is extremely rare (frequency < 1 x 10(6); yet the virtual absence of albumin is tolerable despite its multiple functions), and the mutations identified in three unrelated subjects from different countries occurred at three different sites. Expand
Point substitutions in albumin genetic variants from Asia.
TLDR
It is suggested that some alloalbumins with the same substitution may have originated by independent mutations in various populations, and the apparent clustering of point substitutions in the protein structure may reflect hypermutability of the albumin gene. Expand
Genetic variants of serum albumin in Americans and Japanese.
TLDR
A collaborative search for albumin genetic variants (alloalbumins) was undertaken by cellulose acetate and agarose electrophoresis at pH 8.6 of the sera of patients at two major medical centers in the United States and of nearly 20,000 blood donors in Japan, and seven different alloalbumin types were characterized by structural study. Expand
Purification and structural study of two albumin variants in an Irish population.
TLDR
Two types of variant albumins were detected during routine electrophoresis on cellulose acetate on 34,000 sera from patients in a relatively stable Irish population, with significance for the study of protein evolution and as an aid in identification of drug-binding sites. Expand
Point substitutions in Japanese alloalbumins.
TLDR
The structural study of five rare types of inherited albumin variants discovered in the Biochemical Genetics Study of 15,581 unrelated children in Hiroshima and Nagasaki suggests that point substitutions are grouped in certain segments of the albumin molecule. Expand
Mutation-specific SARS-CoV-2 PCR Screen: Rapid and Accurate Detection of Variants of Concern and the Identification of a Newly Emerging Variant with Spike L452R Mutation
TLDR
Four multiplex mutation-specific PCR-based assays with same-day reporting that can detect five VOCs and three variants of interest (VOIs), as defined in the March 2021 guidelines from the United States (US) Centers for Disease Control and Prevention, are developed. Expand
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