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Selective monomethylation of primary amines with simple electrophiles.
Direct monomethylation of primary amines with methyl triflate was achieved with high selectivity (up to 96%) from the use of HFIP as the solvent that interferes with amines and avoids overmethylation. Expand
Central alpha 1 adrenoceptor subtypes in narcolepsy-cataplexy: a disorder of REM sleep.
The results of in vivo pharmacology and in vitro [3H]prazosin binding in canine narcolepsy now clearly implicate the low affinity alpha 1b binding site (alpha 1b) in canineNarcoleptic dogs. Expand
Central α1 adrenoceptor subtypes in narcolepsy-cataplexy: a disorder of REM sleep
The present study suggests the specific involvement within the central nervous system of an α1 adrenoceptor subtype in a behavior, the control of cataplexy, a pathological analogue of rapid eyeExpand
Recent advances in stereoselective synthesis of 1,3-dienes.
The aim of this review is to present the latest developments in the stereoselective synthesis of conjugated dienes, covering the period 2005-2010, and illustrates the most representative strategies and mechanisms to access these targets. Expand
Putting pressure on elusive polymorphs and solvates
The reproducible crystallisation of elusive polymorphs and solvates of molecular compounds at high pressure has been demonstrated through studies on maleic acid, malonamide, and paracetamol. TheseExpand
Ph2P(BH3)Li: from ditopicity to dual reactivity.
Density functional theory computations show that H(2)P(BH(3))Li exhibits a ditopic character, which explains its dual reactivity (H- or P-addition), both routes going through somewhat similar six-membered transition states with low activation barriers. Expand
Measurement of phenylacetic acid in cerebrospinal fluid and plasma using combined gas chromatography/electron capture chemical ionization mass spectrometry.
Details are presented of an ultra-sensitive gas chromatographic/mass spectrometric assay for phenylacetic acid in plasma and cerebrospinal fluid based on measurements of the relative intensities ofExpand
Influence of freezer storage time on cerebral biogenic amine and metabolite concentrations and receptor ligand binding characteristics
Brains from breed and age-matched canines stored at -80 degrees C for between 3 and 44 months showed a time-dependent decline in the concentration of norepinephrine in the amygdala and dopamine and nore Alpinephrine inThe caudate, suggesting that the decline in dopamine andnorepine cortisol concentrations was not the result of enzymatic breakdown, but probably the resultof chemical decomposition. Expand