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Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate.
DNA-sequence variants associated with IRF6 are major contributors to cleft lip, with or without cleft palate; moreover, the results for some individual populations from South America and Asia were highly significant.
Association of MSX1 and TGFB3 with nonsyndromic clefting in humans.
Nonsyndromic cleft lip with or without cleft palate (CL/P) and nonsyndromic cleft palate only (CPO) are common congenital anomalies with significant medical, psychological, social, and economic…
Complete sequencing shows a role for MSX1 in non-syndromic cleft lip and palate
A population based scan for mutations encompassing the sense and antisense transcribed sequence of MSX1 (two exons, one intron) is described and four rare mutations were found in non-coding regions that are highly conserved and disrupt probable regulatory regions.
FOXE1 association with both isolated cleft lip with or without cleft palate, and isolated cleft palate.
Data indicate that FOXE1 is a major gene for CL/P and provides new insights for improved counseling and genetic interaction studies.
In a Vietnamese population, MSX1 variants contribute to cleft lip and palate
MSX1 contributes to nonsyNDromic clefting in a Vietnamese population, and consistent with other studies, identifiable mutations in this gene cause about 2% of cases of nonsyndromic Cleft lip and palate.
Prognostic factors for keratocystic odontogenic tumor (odontogenic keratocyst): analysis of clinico-pathologic and immunohistochemical findings in cysts treated by enucleation.
- N. Kuroyanagi, H. Sakuma, K. Shimozato
- MedicineJournal of oral pathology & medicine : official…
- 1 April 2009
Evaluation of Ki-67 expression in KCOT at the time of pathological diagnosis might be helpful for consideration of appropriate adjunctive surgical procedures to avoid a recurrence and may serve as a prognostic marker.
Characterization of a novel gene disrupted by a balanced chromosomal translocation t(2;19)(q11.2;q13.3) in a family with cleft lip and palate.
A positional-cloning strategy was used to identify a novel gene disrupted by the translocation on chromosome 19 that was ubiquitously expressed on Northern blots containing RNA from adult tissues and in whole-mount in situ hybridization of day 10 to 12 mouse embryos, suggesting that CLPTM1 may belong to a new gene family.
A single nucleotide polymorphism associated with isolated cleft lip and palate, thyroid cancer and hypothyroidism alters the activity of an oral epithelium and thyroid enhancer near FOXE1.
Quantitative reporter assays in oral epithelial and thyroid cell lines show that the rs7850258 allele (G) associated with CLP and hypothyroidism has significantly greater enhancer activity than the allele associated with thyroid cancer (A).
Natural Course of Untreated Symptomatic Temporomandibular Joint Disc Displacement without Reduction
- K. Kurita, P. Westesson, H. Yuasa, M. Toyama, J. Machida, N. Ogi
- Medicine, PsychologyJournal of dental research
- 1 February 1998
It is indicated that approximately 40% of patients with symptomatic disc displacement without reduction will be free of symptoms within 2.5 years, one-third will improve, whereas one-quarter will continue to be symptomatic.
FOXE 1 association with both isolated cleft lip with or without cleft palate , and isolated cleft palate
This research presents a novel and scalable approach to genome-based approaches to Craniofacial and Dental Genetics that addresses the challenge of “blank-spaced” dentistry.