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Photoaffinity Labeling of a Cell Surface Polyamine Binding Protein (*)
Intracellular polyamine pools are partially maintained by an active transport apparatus that is specific for and regulated by polyamines. Although mammalian transport activity has been characterizedExpand
Synthesis and testing of quinone-based bis(2,2-dimethyl-1-aziridinyl)phosphinyl carbamates as radiation-potentiating antitumor agents.
Two new drug candidates, in which a quinonoid moiety is linked to the reactive bis(2,2-dimethyl-1-aziridinyl)phosphinyl function, have been prepared and tested in vivo for antitumor activity and inExpand
Synthesis of new nucleoside phosphoraziridines as potential site-directed antineoplastic agents.
With the aim of increasing the selectivity of the 2,2-dimethylphosphoraziridine type antitumor agents toward the intracellular site of DNA synthesis, a series of new compounds was synthesized inExpand
Synthesis of potential dual-acting radiation sensitizer antineoplastic agents: 2,2-dimethylphosphoraziridines containing 2-nitroimidazoles or other electron-affinic moieties.
In view of the in vivo demonstrated radiation-potentiating activities of several previously studied 2,2-dimethylphosphoraziridines, six new compounds incorporating theExpand
Synthesis and properties of bis(2,2-dimethylaziridinyl)phosphinic amides: a series of new antineoplastic agents.
In continuation of efforts to improve the antitumor selectivity of the 2,2-dimethylaziridine class of alkylating agents, a series of N-substituted bis(2,2-dimethyl-1-aziridinyl)phosphinic amides hasExpand
Synthesis of 5-Ethyl-2-pyrimidinone-2′-deoxyriboside as a New Potential Antiviral Agent
Abstract 5-Ethyl-2-pyrimidinone (5) and its 2′-deoxyribosides 9 (α) and 10 (β) have been synthesized in several steps starting from 5-ethyluracil. 10 is presented for evaluation against herpes virusExpand
Pharmacokinetics and bioavailability of a newly synthesized dihydropyridine compound with multidrug resistance reversal activity
(+/−)3‐(3‐(4,4‐diphenylpiperidin‐1‐yl)propyl) 5‐methyl 4‐(3,4‐dimethoxyphenyl)‐2,6‐dimethyl‐1,4‐dihydropyridine‐3,5‐dicarboxylate ((±)‐DHP‐014), is a new 4‐aryl‐1,4‐dihydropyridine that can reverseExpand