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RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway
TLDR
It is shown that the cytosolic poly(dA-dT) DNA is converted into 5'-ppp RNA to induce IFN-beta through the RIG-I pathway, suggesting that RNA Pol-III is a cytosol DNA sensor involved in innate immune responses. Expand
Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1
TLDR
Structural and complementary chemical analyses reveal an unexpected mechanism of inhibition involving covalent conjugation and CRM1-mediated hydrolysis of the natural products’ lactone rings. Expand
Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection
TLDR
Mouse and human SAAs are identified as a family of microbe-inducible retinol binding proteins, reveal a unique protein architecture involved in retInol binding, and suggest howretinol is circulated during infection. Expand
Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor.
TLDR
Through a series of biophysical characterizations of inhibitor-protein interactions (NMR and X-ray crystallography), the structural requirements for artificial inhibitors of the HIF-2α-ARNT PAS-B interaction are established and may serve as a foundation for discovering therapeutic agents that function by a novel mode of action. Expand
Structural and Mechanistic Roles of Novel Chemical Ligands on the SdiA Quorum-Sensing Transcription Regulator
TLDR
Several structures of one orphan LuxR-type protein, SdiA, from enterohemorrhagic E. coli (EHEC), in the presence and absence of AHL are presented to open exciting and novel avenues to control shedding of this human pathogen in the environment. Expand
Using Functional Signature Ontology (FUSION) to Identify Mechanisms of Action for Natural Products
TLDR
This approach identified gene products and natural product compounds that regulated processes as diverse as the breakdown of intracellular components, directed cell migration, and survival signaling, and holds promise for facilitating future drug discovery. Expand
Caminosides B-D, antimicrobial glycolipids isolated from the marine sponge Caminus sphaeroconia.
TLDR
A screening program aimed at discovering inhibitors of the bacterial type III secretion system identified the MeOH extract of the Caribbean sponge Caminus sphaeroconia as an active hit in the initial assay, leading to the isolation of caminosides A to D, a family of antimicrobial glycolipids. Expand
Majusculoic acid, a brominated cyclopropyl fatty acid from a marine cyanobacterial mat assemblage.
TLDR
The novel antifungal compound majusculoic acid was isolated from a cyanobacterial mat microbial community by interpretation of mass spectrometric and NMR data and conversion to the corresponding methyl ester. Expand
Lobocyclamides A-C, lipopeptides from a cryptic cyanobacterial mat containing Lyngbya confervoides.
TLDR
The structures of lipopeptides lobocyclamides A, B, and C were solved using a combination of mass spectrometry, 2D NMR spectroscopy, and degradative analysis and exhibited moderate antifungal activity against a panel of Candida spp. Expand
(2S,3R)-2-aminododecan-3-ol, a new antifungal agent from the ascidian Clavelina oblonga.
TLDR
A new antifungal agent, (2S,3R)-2-aminodododecan-3-ol (1), has been isolated from the ascidian Clavelina oblonga collected in Brazil by analysis of spectroscopic data. Expand
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