Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection
- A. Pardiñas, P. Holmans, J. Walters
- Psychology, BiologyNature Genetics
- 26 February 2018
A new genome-wide association study of schizophrenia is reported, and through meta-analysis with existing data and integrating genomic fine-mapping with brain expression and chromosome conformation data, 50 novel associated loci and 145 loci are identified.
Fecundity of patients with schizophrenia, autism, bipolar disorder, depression, anorexia nervosa, or substance abuse vs their unaffected siblings.
- R. Power, S. Kyaga, A. Svensson
- Psychology, MedicineJAMA psychiatry
- 2013
The results suggest that strong selection exists against schizophrenia, autism, and anorexia nervosa and that these variants may be maintained by new mutations or an as-yet unknown mechanism.
Treatment-Resistant Schizophrenia: Treatment Response and Resistance in Psychosis (TRRIP) Working Group Consensus Guidelines on Diagnosis and Terminology.
- O. Howes, R. McCutcheon, C. Correll
- Medicine, PsychologyAmerican Journal of Psychiatry
- 1 March 2017
The authors present consensus guidelines that operationalize criteria for determining and reporting treatment resistance, adequate treatment, and treatment response, providing a benchmark for research and clinical translation in schizophrenia.
Preterm birth and psychiatric disorders in young adult life.
- C. Nosarti, A. Reichenberg, C. Hultman
- Psychology, MedicineArchives of General Psychiatry
- 1 June 2012
Preterm birth was significantly associated with increased risk of psychiatric hospitalization in adulthood in a monotonic manner across a range of psychiatric disorders.
Does tobacco use cause psychosis? Systematic review and meta-analysis
- Pedro Gurillo, S. Jauhar, R. Murray, J. MacCabe
- Psychology, MedicineLancet psychiatry
- 10 July 2015
Advancing maternal age is associated with increasing risk for autism: a review and meta-analysis.
- S. Sandin, C. Hultman, A. Kolevzon, R. Gross, J. MacCabe, A. Reichenberg
- Medicine, PsychologyJournal of the American Academy of Child and…
- 1 May 2012
Regional volume deviations of brain structure in schizophrenia and psychotic bipolar disorder
- C. Mcdonald, E. Bullmore, R. Murray
- Psychology, MedicineBritish Journal of Psychiatry
- 1 May 2005
Background It is unclear whether schizophrenia and psychotic bipolar disorder are associated with similar deviations of brain morphometry. Aims To assess volumetric abnormalities of grey and white…
Excellent school performance at age 16 and risk of adult bipolar disorder: national cohort study
- J. MacCabe, M. Lambe, C. Hultman
- Psychology, MedicineBritish Journal of Psychiatry
- 1 February 2010
Findings provide support for the hypothesis that exceptional intellectual ability is associated with bipolar disorder.
Augmentation of clozapine with electroconvulsive therapy in treatment resistant schizophrenia: A systematic review and meta-analysis
- J. Lally, J. Tully, D. Robertson, B. Stubbs, F. Gaughran, J. MacCabe
- Psychology, MedicineSchizophrenia Research
- 1 March 2016
Antipsychotic medication in schizophrenia: a review.
- J. Lally, J. MacCabe
- Psychology, MedicineBritish Medical Bulletin
- 1 June 2015
Antipsychotic medications are mainstays in the treatment of schizophrenia and a range of other psychotic disorders and future developments will target additional processes, including glutamatergic, cholinergic and cannabinoid receptor targets, allowing for a tailored and safer use of antipsychotics.
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