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Preparation of hypocholesterol peptides from soy protein and their hypocholesterolemic effect in mice
The yield and in vitro hypocholesterolemic activity of low-molecular weight soy protein hydrolysates were studied. The yield and cholesterol micellar solubility inhibitory rate (CMSIR) were higherExpand
Fractionation and identification of a novel hypocholesterolemic peptide derived from soy protein Alcalase hydrolysates
A novel hypocholesterolemic peptide was fractionated by gradient ethanol elution from a macroporous adsorption resin (MAR DA201-C), and then separated on Sephadex G-15 and RP-HPLC from a soy proteinExpand
Aggregation behavior of tetraenoic fatty acids in aqueous solution.
Application of conformation design in acyclic stereoselection: total synthesis of borrelidin as the crystalline benzene solvate.
The total synthesis of (-)-borrelidin (treponemycin), a structurally distinct 18-membered macrolide antibiotic, has been achieved. It was isolated as the crystalline benzene solvate, and itsExpand
Stereocontrolled solution and solid phase enolate alkylations and hydroxylations — generation of three and four contiguous stereogenic carbon atoms in acyclic systems
Abstract Potassium enolates of γ-alkoxy-α-methyl pentanoates can be alkylated with allylic and benzylic halides in solution and on solid phase with high 2,3- syn selectivity. Polypropionate units canExpand
Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors.
The present work describes a series of novel chiral amines that potently inhibit the in vitro reuptake of serotonin, norepinephrine and dopamine (triple reuptake inhibitors) and were active in vivoExpand
Synthesis and pharmacological characterization of bicyclic triple reuptake inhibitor 3-aryl octahydrocyclopenta[c]pyrrole analogues.
The present work expands the chemical space known to offer potent inhibition of the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT) and discloses novelExpand
Synthesis of Novel Rod-Coil Brush Polymers with Conjugated Backbones through Bergman Cyclization
This work reports synthesis of “rod−coil” brush polymers with rigid conjugated backbone. “Grafting through” strategy was employed via combination of ring-opening polymerization (ROP) and BergmanExpand
Complexation of Fatty Acids and Fatty Acid‐CoAs with Synthetic O‐Methylated Polysaccharides
An experimentally simple, but highly reproducible and reliable method has been developed to follow the complexation event of fatty acid (FA) and FA‐CoA with polysaccharides. This method was based onExpand
Minimization of drug-drug interaction risk and candidate selection in a natural product-based class of gamma-secretase modulators.
Early lead compounds in this gamma secretase modulator series were found to potently inhibit CYP3A4 and other human CYP isoforms increasing their risk of causing drug-drug-interactions (DDIs). UsingExpand