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Argonaute2 Is the Catalytic Engine of Mammalian RNAi
Gene silencing through RNA interference (RNAi) is carried out by RISC, the RNA-induced silencing complex. RISC contains two signature components, small interfering RNAs (siRNAs) and Argonaute familyExpand
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The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation
Understanding the molecular mechanisms that regulate cellular proliferation and differentiation is a central theme of developmental biology. MicroRNAs (miRNAs) are a class of regulatory RNAs of ∼22Expand
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A microRNA polycistron as a potential human oncogene
To date, more than 200 microRNAs have been described in humans; however, the precise functions of these regulatory, non-coding RNAs remains largely obscure. One cluster of microRNAs, the mir-17–92Expand
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MicroRNAs Regulate Brain Morphogenesis in Zebrafish
MicroRNAs (miRNAs) are small RNAs that regulate gene expression posttranscriptionally. To block all miRNA formation in zebrafish, we generated maternal-zygotic dicer (MZdicer) mutants that disruptExpand
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Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing.
A hallmark of mammalian embryonic development is the widespread induction of microRNA (miRNA) expression. Surprisingly, the transcription of many of these small, noncoding RNAs is unchanged throughExpand
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Extensive post-transcriptional regulation of microRNAs and its implications for cancer.
MicroRNAs (miRNAs) are short, noncoding RNAs that post-transcriptionally regulate gene expression. While hundreds of mammalian miRNA genes have been identified, little is known about the pathwaysExpand
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microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder
BackgroundmicroRNAs (miRNAs) are small, noncoding RNA molecules that are now thought to regulate the expression of many mRNAs. They have been implicated in the etiology of a variety of complexExpand
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The role of pH in determining the species composition of the human colonic microbiota.
The pH of the colonic lumen varies with anatomical site and microbial fermentation of dietary residue. We have investigated the impact of mildly acidic pH, which occurs in the proximal colon, on theExpand
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Direct Regulation of an Oncogenic Micro-RNA Cluster by E2F Transcription Factors*
Micro-RNAs (miRNAs) are a class of non-coding RNAs that post-transcriptionally regulate gene expression via the RNA interference pathway. In addition to roles in normal development, miRNAs haveExpand
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Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells.
The miR-17-92 locus encodes a cluster of 7 microRNAs transcribed as a single primary transcript. It can accelerate c-Myc induced B cell lymphoma development and is highly expressed in many tumors,Expand
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