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PPARγ signaling and metabolism: the good, the bad and the future
Thiazolidinediones (TZDs) are potent insulin sensitizers that act through the nuclear receptor peroxisome proliferator-activated receptor-γ (PPARγ) and are highly effective oral medications for typeExpand
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White Fat Progenitor Cells Reside in the Adipose Vasculature
White adipose (fat) tissues regulate metabolism, reproduction, and life span. Adipocytes form throughout life, with the most marked expansion of the lineage occurring during the postnatal period.Expand
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Vasculature White Fat Progenitor Cells Reside in the Adipose
http://www.sciencemag.org/cgi/content/full/322/5901/583 version of this article at: including high-resolution figures, can be found in the online Updated information and services,Expand
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Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance
The systemic expression of the bile acid (BA) sensor farnesoid X receptor (FXR) has led to promising new therapies targeting cholesterol metabolism, triglyceride production, hepatic steatosis andExpand
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Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer
Fibroblast growth factor 1 (FGF1) is an autocrine/paracrine regulator whose binding to heparan sulphate proteoglycans effectively precludes its circulation. Although FGF1 is known as a mitogenicExpand
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Hedgehog signaling plays a conserved role in inhibiting fat formation.
Hedgehog (Hh) signals regulate invertebrate and vertebrate development, yet the role of the cascade in adipose development was undefined. To analyze a potential function, we turned to Drosophila andExpand
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A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis
Although feast and famine cycles illustrate that remodelling of adipose tissue in response to fluctuations in nutrient availability is essential for maintaining metabolic homeostasis, the underlyingExpand
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Adipose is a conserved dosage-sensitive antiobesity gene.
Adipose (Adp) is an evolutionarily conserved gene isolated from naturally occurring obese flies homozygous for an adp mutation. Here we show that the anti-obesity function of Adp (worm Y73E7A.9, flyExpand
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Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies.
A common thread among conserved life span regulators lies within intertwined roles in metabolism and energy homeostasis. We show that heterozygous mutations of AMP biosynthetic enzymes extendExpand
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Atf4 Regulates Obesity, Glucose Homeostasis, and Energy Expenditure
OBJECTIVE We evaluate a potential role of activating transcription factor 4 (Atf4) in invertebrate and mammalian metabolism. RESEARCH DESIGN AND METHODS With two parallel approaches—a fatExpand
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