• Publications
  • Influence
Freeze tolerance in animals.
Metabolic rate depression in animals: transcriptional and translational controls
  • K. Storey, J. M. Storey
  • Biology, Medicine
    Biological reviews of the Cambridge Philosophical…
  • 1 February 2004
The role of differential gene expression in supplying protein products that adjust metabolism or protect cell functions for long‐term survival, and the mechanisms of protein life extension in hypometabolism involving inhibitory controls of transcription, translation and protein degradation are focused on.
Metabolic Rate Depression and Biochemical Adaptation in Anaerobiosis, Hibernation and Estivation
The present review focuses on the molecular control mechanisms that regulate and coordinate cellular metabolism for the transition into dormancy, which form a common molecular basis for metabolic depression in anoxia-tolerant vertebrates and invertebrates, hibernation in small mammals, and estivation in land snails and terrestrial toads.
Low toxic herbicide Roundup induces mild oxidative stress in goldfish tissues.
This is the first study to demonstrate a systematic response by the antioxidant systems of fish to Roundup exposure, which suppressed the activities of superoxide dismutase, glutathione S-transferase, Glutathione reductase and glucose-6-phosphate dehydrogenase in fish tissues.
Biochemistry of Cryoprotectants
The role of polyhydric alcohols in cryoprotection is probably the most extensively studied feature of insect cold hardiness. The importance of glycerol as a cryoprotectant was first recognized by R.
Hypoxia and recovery perturb free radical processes and antioxidant potential in common carp (Cyprinus carpio) tissues.
Responses by antioxidant defenses in carp organs appear to include preparatory increases during hypoxia by some antioxidant enzymes in brain but a more direct response to oxidative insult during recovery appears to trigger enzyme responses in kidney and skeletal muscle.
Hatchling turtles survive freezing during winter hibernation.
Hatchlings of the painted turtle (Chrysemys picta marginata) are unique as the only reptile and highest vertebrate life form known to tolerate the natural freezing of extracellular body fluids during winter hibernation, and a survey of possible cryoprotectants revealed a 2- to 3-fold increase in glucose content of liver and blood and a 3- fold increase in blood glycerol in response to freezing.
Various metabolic adaptations for freezing survival appear to have evolved out of pre-existing physiological capacities of animals, including desiccation-resistance and anoxia-tolerance, which helps animals reactivate vital functions after days or weeks of continuous freezing.
Freeze tolerance and intolerance as strategies of winter survival in terrestrially-hibernating amphibians.
The ability to tolerate extracellular freezing as an adaptation for winter survival was tested in seven species of terrestrially-hibernating amphibians found in eastern Canada, finding that the major winter strategy of these animals appears to behavioural avoidance of subzero temperatures.