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Bladder Tumors in Rats Fed Cyclohexylamine or High Doses of a Mixture of Cyclamate and Saccharin
Papillary transitional cell tumors were found in the urinary bladders in 8 rats out of 80 that received 2600 milligrams per kilogram of body weight per day of a mixture of sodium cyclamate and sodium…
A Comparison of the Intracellular Composition of Regenerating Liver and Induced Liver Tumors
Homogenates of regenerating rat livers were separated by differential centrifugation into nuclear, large granule, small granules, and supernatant fluid fractions at various times in the first 8 days and at 23 days after partial hepatectomy, and the ratio of pentosenucleic acid to protein nitrogen was increased in all fractions during rapid growth.
Naturally occurring and braken-fern-induced bovine urinary bladder tumors. Clinical and morphological characteristics.
Hematuria was prominent and occurred as early as 60 days after braken fern feeding began, whereas anemia and changes in leukocytes were late manifestations, and there were papillomas and carcinomas in fern-fed cows.
The carcinogenic activity of some 5-nitrofuran derivatives in the rat.
Three 5-nitrofuran derivatives showed carcinogenic activity when fed to female Holtzman rats at levels of 0.1 to 0.3% in a commercial diet for up to 44.5 weeks, while 2 of the nitrofurans were not carcinogenic, however, the possibility that the observed carcinogenic activities might have been due to the hydrazine or thiazole moieties also is discussed.
Urinary bladder neoplasms induced by feeding bracken fern (Pteris aquilina) to cows.
The histologic appearance of the neoplasms and other parameters of the study suggest that this experiment has resulted in the production of lesions that are indistinguishable from the naturally occurring bovine bladder tumors which are a common feature of bovines enzootic hematuria.
Comparative urinary and gallbladder carcinogenicity of N-(4-(5-nitro-2-furyl)-2-thiazolyl)formamide and N-(4-(5-nitro-2-furyl)-2-thiazolyl)acetamide in the dog.
Naturally Occurring and Bracken-Fern-Induced Bovine Urinary Bladder Tumors
Clinical and morphological characteristics of 139 naturally occurring and 20 bracken-fern-induced urinary bladder tumors of cows were studied. Hematuria was prominent and occurred as early as 60 days…
Lymphatic leukemia and pulmonary tumors in female Swiss mice fed bracken fern (Pteris aquilina).
Bracken fern mixed with a grain mixture was fed to a group of 40 female 6-week-old Swiss mice intermittently every other week for a total experimental period of 60 weeks and thirty-three mice survived 30 or more weeks and all developed lymphatic leukemia with multiple organ involvement.
The production of carcinoma of the urinary bladder in rats by feeding N-[3-(5-nitro-2-furyl)-2-thiazolyl]formamide.
The first nitrofuran derivative which has been found to be a bladder carcinogen, and the compound appears to be one of the most effective bladder carcinogens for this species.
Pathogenesis, histology, and transplantability of urinary bladder carcinomas induced in albino rats by oral administration of N-(4-(5-nitro-2-furyl)-2-thiazolyl)formamide.
N-[4-(5-Nitro-2-furyl)-2-thiazolyl]formamide appears to be one of the most effective urinary bladder carcinogens for both male and female Sprague-Dawley rats, providing carcinomas exhibiting all criteria of malignancy.