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Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers
There was a trend towards a higher infection rate in participants younger than 30 years compared to those older than 50 years, with a reduction in log odds of positivity by 0·035 per year, and the mean duration of SARS-CoV-2 detection was 29 days.
Two putative protein export regulators promote Plasmodium blood stage development in vivo.
- J. M. Matz, K. Matuschewski, T. Kooij
- Biology, MedicineMolecular and biochemical parasitology
- 1 September 2013
Five components of the candidate Plasmodium translocon of exported proteins (PTEX) are examined, a complex thought to mediate protein export across the parasitophorous vacuole membrane into the host cell, suggesting essential functions for EXP2, PTEX150, and heat shock protein 101 (HSP101) during blood stage development.
In Vivo Function of PTEX88 in Malaria Parasite Sequestration and Virulence
- J. M. Matz, Alyssa Ingmundson, Jean Costa Nunes, W. Stenzel, K. Matuschewski, T. W. Kooij
- Medicine, BiologyEukaryotic Cell
- 27 March 2015
The presented data suggest that the protein export machinery of Plasmodium parasites and their underlying mechanistic features are considerably more complex than previously anticipated and indicate challenges for targeted intervention strategies.
The Plasmodium berghei translocon of exported proteins reveals spatiotemporal dynamics of tubular extensions
Together, live cell imaging and correlative light and electron microscopy permitted previously unrecognized spatiotemporal and subcellular resolution of PTEX-containing tubules in murine malaria parasites, which further refine current models for Plasmodium-induced erythrocyte makeover.
Estimating the effectiveness of routine asymptomatic PCR testing at different frequencies for the detection of SARS-CoV-2 infections
Routine asymptomatic testing can enable detection of a high proportion of infected individuals early in their infection, provided that the testing is frequent and the time from testing to notification of results is sufficiently fast.
Plasmodium Para-Aminobenzoate Synthesis and Salvage Resolve Avoidance of Folate Competition and Adaptation to Host Diet.
- J. M. Matz, Mutsumi Watanabe, M. Falade, Takayuki Tohge, R. Hoefgen, K. Matuschewski
- Biology, MedicineCell reports
- 1 January 2019
It is shown that the malaria parasite depends on de novo folate synthesis only when dietary intake by the mammalian host is restricted and that only pABA, rather than fully formed folate, is taken up efficiently.
Vital and dispensable roles of Plasmodium multidrug resistance transporters during blood‐ and mosquito‐stage development
- S. Rijpma, M. van der Velden, +15 authors J. B. Koenderink
- Biology, MedicineMolecular microbiology
- 1 July 2016
Vital and dispensable roles of MDR proteins during blood stages and an important function in sporogony for MDR2 and MDR5 in both Plasmodium species are demonstrated.
Identification of clustered organellar short (cos) RNAs and of a conserved family of organellar RNA-binding proteins, the heptatricopeptide repeat proteins, in the malaria parasite
- A. Hillebrand, J. M. Matz, Martin Almendinger, K. Müller, K. Matuschewski, C. Schmitz-Linneweber
- Biology, MedicineNucleic acids research
- 8 August 2018
The identification of clustered organellar short RNA fragments that are possible footprints of RNA-binding proteins (RBPs) in Plasmodium organelles that are hypothesize that these are footprints of RBPs involved in assembling the rRNA fragments into a functioning ribosome.
Scalable and robust SARS-CoV-2 testing in an academic center
A roadmap is provided to show how a European research institute can be repurposed in the midst of this crisis, in collaboration with partner hospitals and an established diagnostic laboratory, harnessing existing expertise in virus handling, robotics, molecular testing and informatics to derive a rapid, high-throughput diagnostic testing pipeline for detecting SARS-CoV-2 in individuals with suspected COVID-19.
The parasitophorous vacuole of the blood-stage malaria parasite
The origin, development, molecular composition and functions of the parasitophorous vacuole of Plasmodium blood stages and the relevance of the malaria parasite’s intravacuolar lifestyle for successful erythrocyte infection are discussed and perspectives for future research directions are provided.