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Modulation of the neuronal dopamine transporter activity by the metabotropic glutamate receptor mGluR5 in rat striatal synaptosomes through phosphorylation mediated processes
There is considerable evidence that the activity of the neuronal dopamine transporter (DAT) is dynamically regulated and a putative implication of its phosphorylation in this process has beenExpand
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Prospects for pharmacological intervention in Alzheimer disease.
Alzheimer disease (AD) involves neuronal degeneration with impaired cholinergic transmission in the cerebral cortex and hippocampus in areas of the brain particularly associated with memory andExpand
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Dopamine receptors--physiological understanding to therapeutic intervention potential.
There are two families of dopamine (DA) receptors, called D1 and D2, respectively. The D1 family consists of D1- and D5-receptor subtypes and the D2 family consists of D2-, D3-, and D4-receptorExpand
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GABA induces down-regulation of the benzodiazepine-GABA receptor complex in the rat cultured neurons.
Cultured neurons from embryonic rat brain display central type benzodiazepine receptors characterized by high-affinity binding of [3H]flunitrazepam which is allosterically enhanced in the presence ofExpand
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Mechanisms of regulation of neurotensin receptors.
Since its discovery in 1973, the neuropeptide neurotensin has been demonstrated to be involved in the control of a broad variety of physiological activities in both the central nervous system and inExpand
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Absence of mutation in the beta-amyloid cDNAs cloned from the brains of three patients with sporadic Alzheimer's disease.
Using an oligonucleotide probe, we isolated cDNA clones corresponding to the precursor of the beta-amyloid peptide (BAP) from brain libraries of 3 patients with sporadic Alzheimer's disease (AD). DNAExpand
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Cytoskeleton‐related trafficking of the EAAC1 glutamate transporter after activation of the Gq/11‐coupled neurotensin receptor NTS1
The possible modulation of the glutamate transporter EAAC1 by a class A G protein‐coupled receptor was studied in transfected C6 glioma cells stably expressing the high‐affinity neurotensin receptorExpand
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Impact of genomics on drug discovery and clinical medicine.
Genomics, particularly high-throughput sequencing and characterization of expressed human genes, has created new opportunities for drug discovery. Knowledge of all the human genes and their functionsExpand
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[3H]GBR 12935 binding to dopamine uptake sites: subcellular localization and reduction in Parkinson's disease and progressive supranuclear palsy.
[3H]GBR 12935 bound with high affinity to dopamine uptake sites in rat striatum where a close parallelism was observed between the subcellular localization profiles for [3H]dopamine uptake andExpand
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Rapid agonist-induced decrease of neurotensin receptors from the cell surface in rat cultured neurons.
The regulation of neurotensin receptors was studied in vitro in primary cultures of neuronal cells. High affinity receptors for [3H]neurotensin were found in homogenates and at the cell surface ofExpand
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