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Inflammatory mediator-induced hypothalamic-pituitary-adrenal axis activation is defective in streptococcal cell wall arthritis-susceptible Lewis rats.
- E. Sternberg, J. M. Hill, +4 authors R. Wilder
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 April 1989
Inbred Lewis (LEW/N) female rats develop an arthritis in response to group A streptococcal cell wall peptidoglycan polysaccharide (SCW), which mimics human rheumatoid arthritis. Histocompatible… Expand
AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC
- V. Sagulenko, S. Thygesen, +9 authors K. Stacey
- Biology, Medicine
- Cell Death and Differentiation
- 1 September 2013
Inflammasomes are protein complexes assembled upon recognition of infection or cell damage signals, and serve as platforms for clustering and activation of procaspase-1. Oligomerisation of initiating… Expand
Pseudomonas aeruginosa protease IV enzyme assays and comparison to other Pseudomonas proteases.
- A. Caballero, J. Moreau, L. Engel, M. Marquart, J. M. Hill, R. O'Callaghan
- Biology, Medicine
- Analytical biochemistry
- 15 March 2001
Pseudomonas aeruginosa secretes multiple proteases that have been implicated as virulence factors and the detection of each specific enzyme can be difficult to determine. Unlike the three Pseudomonas… Expand
Prevention of fetal demise and growth restriction in a mouse model of fetal alcohol syndrome.
- C. Spong, D. Abebe, I. Gozes, D. Brenneman, J. M. Hill
- The Journal of pharmacology and experimental…
- 1 May 2001
Two peptides [NAPVSIPQ (NAP) and SALLRSIPA (ADNF-9)], that are associated with novel glial proteins regulated by vasoactive intestinal peptide, are shown now to provide protective intervention in a… Expand
Autoradiographic localization of insulin receptors in rat brain: Prominence in olfactory and limbic areas
The binding of 125I-labeled insulin in thin sections of frozen fresh rat brain (95% specific binding) was shown using autoradiography. By several criteria including structure-activity relationship… Expand
Strain specificity of spontaneous and adrenergically induced HSV-1 ocular reactivation in latently infected rabbits.
Spontaneous ocular shedding and adrenergic induction of ocular shedding were examined in rabbits infected with ten strains of herpes simplex virus type 1 (HSV-1): McKrae, KOS, F, Rodanus, 17 Syn+,… Expand
Expression of multiple alpha adrenergic receptor subtype messenger RNAs in the adult rat brain
Multiple subtypes of alpha adrenergic receptors with CNS expression (alpha 1A, alpha 1B, alpha 2A and alpha 2C) have been identified through pharmacological and molecular biological means. To… Expand
The herpes simplex virus latency-associated transcript is spliced during the latent phase of infection.
The herpes simplex virus type 1 latency-associated transcript (LAT) is expressed as a major species 2,100 to 2,200 bases in length and a less abundant one ca. 730 bases shorter in latently infected… Expand
Protease IV, a Unique Extracellular Protease and Virulence Factor from Pseudomonas aeruginosa *
- L. Engel, J. M. Hill, A. Caballero, L. Green, R. O'Callaghan
- Medicine, Biology
- The Journal of Biological Chemistry
- 3 July 1998
Comparisons of virulence between aPseudomonas parent strain and an isogenic mutant devoid of protease IV have demonstrated a significant role for this enzyme during infection. We have characterized… Expand
Herpes simplex virus latent phase transcription facilitates in vivo reactivation.
The biological role of latent phase transcripts was studied in a rabbit model of herpes simplex virus type I (HSV-I) ocular reactivation. Virus X10-13, a variant of HSV which does not express latency… Expand