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Regulation of Raf-1 by direct feedback phosphorylation.
The Raf-1 kinase is an important signaling molecule, functioning in the Ras pathway to transmit mitogenic, differentiative, and oncogenic signals to the downstream kinases MEK and ERK. Because of itsExpand
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Negative feedback regulation of the ERK1/2 MAPK pathway
The extracellular signal-regulated kinase 1/2 (ERK1/2) mitogen-activated protein kinase (MAPK) signalling pathway regulates many cellular functions, including proliferation, differentiation, andExpand
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ERK5: structure, regulation and function.
Extracellular signal-regulated kinase 5 (ERK5), also termed big mitogen-activated protein kinase-1 (BMK1), is the most recently identified member of the mitogen-activated protein kinase (MAPK) familyExpand
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Association of the Adaptor TANK with the IκB Kinase (IKK) Regulator NEMO Connects IKK Complexes with IKKε and TBK1 Kinases*
Canonical activation of NF-κB is mediated via phosphorylation of the inhibitory IκB proteins by the IκB kinase complex (IKK). IKK is composed of a heterodimer of the catalytic IKKα and IKKβ subunitsExpand
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ERK5 is required for VEGF-mediated survival and tubular morphogenesis of primary human microvascular endothelial cells
Extracellular signal-regulated kinase 5 (ERK5) is activated in response to environmental stress and growth factors. Gene ablation of Erk5 in mice is embryonically lethal as a result of disruption ofExpand
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BRACHYURY confers cancer stem cell characteristics on colorectal cancer cells
Cancer stem cells (CSCs) are initiating cells in colorectal cancer (CRC). Colorectal tumours undergo epithelial to mesenchymal transition (EMT)‐like processes at the invasive front, enabling invasionExpand
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ERK5 and the regulation of endothelial cell function.
ERK5 (extracellular-signal-regulated kinase 5), also termed BMK1 [big MAPK1 (mitogen-activated protein kinase 1)], is the most recently discovered member of the MAPK family. It is expressed in aExpand
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Short photoperiod-dependent down-regulation of thyrotropin-alpha and -beta in hamster pars tuberalis-specific cells is prevented by pinealectomy.
Hamster hypophyseal pars tuberalis (PT)-specific cells are characterized by the expression of common alpha-chain and TSH beta. Immunoreactivity for these subunits and the morphology of these cellsExpand
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Hemophagocytic lymphohistiocytosis in syntaxin-11-deficient mice: T-cell exhaustion limits fatal disease.
Syntaxin-11 (Stx11), an atypical member of the SNARE protein family, is part of the cytolytic machinery of T and NK cells and involved in the fusion of lytic granules with the plasmamembrane.Expand
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Syntaxin 11 is required for NK and CD8+ T‐cell cytotoxicity and neutrophil degranulation
Syntaxin 11 (STX11) controls vesicular trafficking and is a key player in exocytosis. Since Stx11 mutations are causally associated with a familial hemophagocytic lymphohistio‐cytosis, we wanted toExpand
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