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Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid
TLDR
The cloning of complementary DNA encoding an extracellular Ca2+ -sensing receptor from bovine parathyroid is reported with pharmacological and functional properties nearly identical to those of the native receptor. Expand
Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps.
The role of ATP-dependent calcium uptake into intracellular storage compartments is an essential feature of hormonally induced calcium signaling. Thapsigargin, a non-phorboid tumor promoter,Expand
Functional comparisons between isoforms of the sarcoplasmic or endoplasmic reticulum family of calcium pumps.
TLDR
These properties are consistent with an enzyme in which the equilibrium between the E1 and E2 conformations is shifted toward the E2 state. Expand
Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney.
TLDR
Northern blot analysis and in situ hybridization indicate that these transporters are expressed predominantly in kidney with an intrarenal distribution consistent with their recognized functional localization, establishing a new family of Na(+)-(K+)-Cl- cotransporters. Expand
Cloning and expression of an inwardly rectifying ATP-regulated potassium channel
TLDR
A complementary DNA encoding an ATP-regulated potassium channel has been isolated by expression cloning from rat kidney and the presence of an H5 region, which is likely to form the ion conduction pathway, indicates that the protein may share a common origin with voltage-gated potassium channel proteins. Expand
Na+/Ca2+ exchangers: three mammalian gene families control Ca2+ transport.
  • J. Lytton
  • Biology, Medicine
  • The Biochemical journal
  • 15 September 2007
TLDR
Mammalian Na+/Ca2+ exchangers are members of three branches of a much larger family of transport proteins whose main role is to provide control of Ca2+ flux across the plasma membranes or intracellular compartments. Expand
Primary structure and functional expression of a cDNA encoding the thiazide-sensitive, electroneutral sodium-chloride cotransporter.
TLDR
The pharmacological and kinetic characteristics of the cloned cotransporter are consistent with the properties of native thiazide-sensitive, electroneutral sodium-chloride cOTransporters in teleost urinary bladder and mammalian renal distal tubule epithelia. Expand
Enrichment of Endoplasmic Reticulum with Cholesterol Inhibits Sarcoplasmic-Endoplasmic Reticulum Calcium ATPase-2b Activity in Parallel with Increased Order of Membrane Lipids
TLDR
It is speculated that SERCA2b, a conformationally active protein with 11 membrane-spanning regions, loses function due to decreased conformational freedom in FC-ordered membranes, which may underlie the critical connection between excess cholesterol, unfolded protein response induction, macrophage death, and plaque destabilization in advanced atherosclerosis. Expand
The cation/Ca(2+) exchanger superfamily: phylogenetic analysis and structural implications.
  • X. Cai, J. Lytton
  • Biology, Medicine
  • Molecular biology and evolution
  • 1 September 2004
TLDR
A comprehensive sequence alignment and the first phylogenetic analysis of the cation/Ca(2+) exchanger superfamily of 147 sequences are reported, suggesting unique signature motifs of conserved residues that may underlie divergent functional properties. Expand
Tissue-specific expression of Na(+)-Ca2+ exchanger isoforms.
TLDR
It is proposed that the structural complexity of the single NCE gene allows it to respond independently to the unique demands of different environments and is controlled and regulated under the influence of different promoters in a tissue-specific fashion. Expand
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