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Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-β
Classical endocrine studies have shown that steroid hormones are required for the maintenance of pregnancy and placental viability. The oestrogen-receptor-related receptor β (ERR-β) is an orphanExpand
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Reduced Fat Mass in Mice Lacking Orphan Nuclear Receptor Estrogen-Related Receptor α
ABSTRACT The estrogen-related receptor α (ERRα) is an orphan member of the superfamily of nuclear hormone receptors expressed in tissues that preferentially metabolize fatty acids. Despite theExpand
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Mice lacking all isoforms of retinoic acid receptor β develop normally and are susceptible to the teratogenic effects of retinoic acid
Retinoic acids (RA) are vitamin A derivatives essential for normal embryonic development and viability of vertebrates. The RA signal is mediated by two distinct classes of receptors, RA receptorsExpand
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Compound mutants for retinoic acid receptor (RAR)β and RARα1 reveal developmental functions for multiple RARβ isoforms
Mice with targeted disruptions in retinoic acid receptor genes have been generated to assess the role of nuclear receptors as transducers of the retinoid signal during vertebrate development. MiceExpand
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Effects of partial hepatectomy on hepatic insulinlike growth factor binding protein‐1 expression
Insulinlike growth factor binding proteins modulate the action of the insulinlike growth factors in various bioassays and may regulate the bioavailability of the insulinlike growth factors in vivo.Expand
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Inhibition of the regulation of intracellular pH: potential of 5-(N,N-hexamethylene) amiloride in tumour-selective therapy.
The viability of cells within the acidic microenvironment found in solid tumours is expected to depend on the regulation of intracellular pH (pHi). 5-(N,N-hexamethylene) amiloride (HMA) is a potentExpand
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Functionalized cell-free scaffolds for bone defect repair inspired by self-healing of bone fractures: A review and new perspectives.
  • L. Li, Hongwei Lu, +4 authors Q. He
  • Materials Science, Medicine
  • Materials science & engineering. C, Materials for…
  • 1 May 2019
Studies have demonstrated that scaffolds, a component of bone tissue engineering, play an indispensable role in bone repair. However, these scaffolds involving ex-vivo cultivated cells seeded haveExpand
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Increased Renal Aldose Reductase Activity, Immunoreactivity, and mRNA in Streptozocin-Induced Diabetic Rats
Increased accumulation of renal sorbitol has been documented in the diabetic rat, and it has been suggested that this accumulation may be important in the pathogenesis of diabetic nephropathy. It isExpand
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Endocrine and carbohydrate responses to interleukin-6 in vivo.
The role of interleukin-6 (IL-6) in carbohydrate metabolism beyond its inhibition of hepatic phosphoenolpyruvate carboxykinase has not been widely pursued. To describe such IL-6 effects, we examinedExpand
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Role of protein phosphatases in the activation of CFTR (ABCC7) by genistein and bromotetramisole.
Genistein and bromotetramisole (Br-t) strongly activate cystic fibrosis transmembrane conductance regulator (CFTR; ABCC7) chloride channels on Chinese hamster ovary cells and human airway epithelialExpand
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