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- Publications
- Influence
Enrichment of tomato fruit with health-promoting anthocyanins by expression of select transcription factors
- E. Butelli, L. Titta, +8 authors C. Martin
- Biology, Medicine
- Nature Biotechnology
- 26 October 2008
Dietary consumption of anthocyanins, a class of pigments produced by higher plants, has been associated with protection against a broad range of human diseases. However, anthocyanin levels in the… Expand
Specific Inhibition of Cyclooxygenase 2 Restores Antitumor Reactivity by Altering the Balance of IL-10 and IL-12 Synthesis1
- M. Stolina, S. Sharma, +9 authors S. Dubinett
- Biology, Medicine
- The Journal of Immunology
- 1 January 2000
Cyclooxygenase-2 (COX-2), the enzyme at the rate-limiting step of prostanoid production, has been found to be overexpressed in human lung cancer. To evaluate lung tumor COX-2 modulation of antitumor… Expand
Autocrine/Paracrine Prostaglandin E2 Production by Non-small Cell Lung Cancer Cells Regulates Matrix Metalloproteinase-2 and CD44 in Cyclooxygenase-2-dependent Invasion*
- M. Dohadwala, R. K. Batra, +5 authors S. Dubinett
- Biology, Medicine
- The Journal of Biological Chemistry
- 27 December 2002
Tumor cyclooxygenase-2 (COX-2) expression is known to be associated with enhanced tumor invasiveness. In the present study, we evaluated the importance of the COX-2 product prostaglandin E2 (PGE2)… Expand
New therapy targeting differential androgen receptor signaling in prostate cancer stem/progenitor vs. non-stem/progenitor cells.
- S. Lee, Zhifang Ma, +12 authors C. Chang
- Biology, Medicine
- Journal of molecular cell biology
- 1 February 2013
The androgen deprivation therapy (ADT) to systematically suppress/reduce androgens binding to the androgen receptor (AR) has been the standard therapy for prostate cancer (PCa); yet, most of ADT… Expand
Mechanisms and regulation of cholesterol homeostasis
Cholesterol homeostasis is vital for proper cellular and systemic functions. Disturbed cholesterol balance underlies not only cardiovascular disease but also an increasing number of other diseases… Expand
Blocking miR396 increases rice yield by shaping inflorescence architecture
Strategies to increase rice productivity to meet the global demand have been the main concern of breeders around the world. Although a growing number of functional genes related to crop yield have… Expand
Non-small Cell Lung Cancer Cyclooxygenase-2-dependent Invasion Is Mediated by CD44*
- M. Dohadwala, J. Luo, +7 authors S. Dubinett
- Biology, Medicine
- The Journal of Biological Chemistry
- 15 June 2001
Elevated tumor cyclooxygenase (COX-2) expression is associated with increased angiogenesis, tumor invasion, and suppression of host immunity. We have previously shown that genetic inhibition of tumor… Expand
A novel hydrogen peroxide biosensor based on Au-graphene-HRP-chitosan biocomposites
- Kangfu Zhou, Yihua Zhu, X. Yang, J. Luo, C. Li, Shaorong Luan
- Chemistry
- 30 March 2010
Abstract Graphene was prepared successfully by introducing –SO 3 − to separate the individual sheets. TEM, EDS and Raman spectroscopy were utilized to characterize the morphology and composition of… Expand
Intratumoral administration of adenoviral interleukin 7 gene-modified dendritic cells augments specific antitumor immunity and achieves tumor eradication.
- P. W. Miller, S. Sharma, +8 authors S. Dubinett
- Medicine
- Human gene therapy
- 2000
In two murine lung cancer models adenoviral interleukin 7-transduced dendritic cells (DC-AdIL-7) were administered intratumorally, resulting in complete tumor regression. Intratumoral DC-AdIL-7… Expand
IL-7 inhibits fibroblast TGF-β production and signaling in pulmonary fibrosis
- M. Huang, S. Sharma, +10 authors S. Dubinett
- Biology
- 1 April 2002
Based on studies by our group and others, we hypothesized that IL-7 may possess antifibrotic activities in an IFN-gamma-dependent and independent manner. Here, we have evaluated the antifibrotic… Expand