• Publications
  • Influence
Remdesivir for the Treatment of Covid-19 — Final Report
TLDR
The data show that remdesivir was superior to placebo in shortening the time to recovery in adults who were hospitalized with Covid-19 and had evidence of lower respiratory tract infection.
Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection.
TLDR
The initiation of antiretroviral therapy in HIV-positive adults with a CD4+ count of more than 500 cells per cubic millimeter provided net benefits over starting such therapy in patients after the CD4+, but the risks of unscheduled hospital admissions were similar in the two groups.
Inflammatory and Coagulation Biomarkers and Mortality in Patients with HIV Infection
TLDR
IL-6 and D-dimer were strongly associated with an increased risk of all-cause mortality and Therapies that reduce the inflammatory response to HIV and decrease IL- 6 and D -dimer levels may warrant investigation.
Class of antiretroviral drugs and the risk of myocardial infarction.
TLDR
Investigation of the association of cumulative exposure to protease inhibitors and nonnucleoside reverse-transcriptase inhibitors with the risk of myocardial infarction found no evidence of such an association for nonn nucleosidereverse-transcriptionase inhibitors; however, the number of person-years of observation for exposure to this class of drug was less than that for Exposure to prote enzyme inhibitors.
CD4+ count-guided interruption of antiretroviral treatment.
TLDR
Episodic antiretroviral therapy guided by the CD4+ count significantly increased the risk of opportunistic disease or death from any cause, as compared with continuous antireteviral therapy, largely as a consequence of lowering theCD4+ cell count and increasing the viral load.
Liver-related deaths in persons infected with the human immunodeficiency virus: the D:A:D study.
TLDR
A strong association between immunodeficiency and risk of liver-related death was found and long-term follow-up is required to investigate whether clinically significant treatment-associated liver- related mortality will develop.
Combination antiretroviral therapy and the risk of myocardial infarction.
TLDR
Combination antiretroviral therapy was independently associated with a 26 percent relative increase in the rate of myocardial infarction per year of exposure during the first four to six years of use, however, the absolute risk of my Cardiac Infarction was low and must be balanced against the marked benefits from antireTroviral treatment.
Current Epidemiology of Pneumocystis Pneumonia
Changes in incidence of PCP, groups at risk for PCP, and possible trends in the disease are discussed.
...
...