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High nitric oxide production in human paranasal sinuses
It is reported that NO in humans is produced by epithelial cells in the paranasal sinuses and is present in sinus air in very high concentrations, close to the highest permissible atmospheric pollution levels. Expand
Intragastric nitric oxide production in humans: measurements in expelled air.
High values of nitric oxide in expelled air from the stomach were shown in humans by chemiluminescence technique and this source of NO may be of importance for the integrity of the gastric mucosa in health and disease. Expand
Vanilloid (capsaicin) receptors in the rat: distribution in the brain, regional differences in the spinal cord, axonal transport to the periphery, and depletion by systemic vanilloid treatment
The present results suggest a discrete expression of vanilloid receptors in the brain stem (sensory nuclei); although intrinsic vanilloids receptor-expressing neurons are though to exist in the rat brain, they remain undetected by the present [3H]RTX autoradiography methodology. Expand
Increased amount of nitric oxide in exhaled air of asthmatics.
Exhaled NO may be used to instantly monitor ongoing bronchial inflammation, at least when involving inducible NO synthase, since increased production of NO in the lower airways may involve activated macrophages or neutrophils. Expand
Primarily nasal origin of exhaled nitric oxide and absence in Kartagener's syndrome.
The results clearly show that all NO in exhaled air of healthy subjects originates from the upper respiratory tract, with only a minor contribution from the lower airways, and the absence of nasal NO in children with Kartagener's syndrome could be of use as a simple noninvasive diagnostic test. Expand
Greatly increased luminal nitric oxide in ulcerative colitis
A role for nitric oxide in ulcerative colitis has been suggested and luminal NO is rapidly and easily measurable and may be used to monitor inflammatory bowel disease. Expand
Polypeptide-containing neurons in airway smooth muscle.
Capsaicin-induced desensitization of airway mucosa to cigarette smoke, mechanical and chemical irritants
It is reported here that cigarette smoke as well as light mechanical or local chemical irritation and vagal nerve stimulation induced a subepithelial oedema in the rat trachea and bronchial tree, as indicated by extravasation of Evans blue. Expand
Elevated plasma endothelin-1 concentrations are associated with the severity of illness in patients with sepsis.
The results indicate that endothelin-1 concentrations are correlated with the severity of illness and depression of cardiac output in patients with sepsis. Expand