• Publications
  • Influence
Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease.
TLDR
Findings in 20 patients with nonalcoholic steatohepatitis of unknown cause found the patients were moderately obese, and many had obesity-associated diseases, such as diabetes mellitus and cholelithiasis. Expand
Chronic hepatitis. An update on terminology and reporting.
TLDR
For the reporting practice of pathologists, it is recommended that the pathologist routinely sign out biopsy samples with features of chronic hepatitis by indicating etiology, grade, and stage, which eliminates ambiguous terminology and avoids the risk of inappropriate treatment. Expand
Primary sclerosing cholangitis: Natural history, prognostic factors and survival analysis
  • Russell H. Wiesner, Patricia M. Grambsch, +7 authors Nicholas F. Larusso
  • Medicine
  • Hepatology
  • 1 October 1989
TLDR
Multivariate analysis (Cox proportional hazards regression modeling) revealed that age, serum bilirubin concentration, blood hemoglobin concentration, presence or absence of inflammatory bowel disease and histologic stage on liver biopsy were independent predictors of high risk of dying. Expand
Ursodeoxycholic acid or clofibrate in the treatment of non‐alcohol‐induced steatohepatitis: A pilot study
TLDR
Treatment of NASH with UDCA for 12 months resulted in significant improvement in alkaline phosphatase, ALT, GGT, and hepatic steatosis, but despite the known lipid‐lowering effects of clofibrate, it did not appear to be of clinical benefit in the treatment ofNASH in this 1‐year pilot study. Expand
Staging of chronic nonsuppurative destructive cholangitis (syndrome of primary biliary cirrhosis)
TLDR
Staging of liver biopsy specimens from patients with chronic non-suppurative destructive cholangitis (CNDC) has become an important part of clinical studies that are currently done in many centers, and methods based on uniform criteria that are applicable to all specimens and are easily reproducible are suggested. Expand
Banff schema for grading liver allograft rejection: An international consensus document
TLDR
A panel of recognized experts in liver transplantation pathology, hepatology, and surgery agreed on a common nomenclature and a set of histopathological criteria for the grading of acute liver allograft rejection, and a preferred method of reporting. Expand
Ursodeoxycholic acid in the treatment of primary biliary cirrhosis.
TLDR
UDCA was extraordinarily safe and well tolerated, and its use was associated with delayed progression of the disease as defined in this study, however, the lack of effects on symptoms, histology, and the need for liver transplantation or survival indicate that further evaluation is necessary. Expand
Recurrence of primary sclerosing cholangitis following liver transplantation
  • Ivo W. Graziadei, R. Wiesner, +10 authors Ruud A. Krom
  • Medicine
  • Hepatology
  • 1 April 1999
TLDR
Investigating the recurrence of primary sclerosing cholangitis following liver transplantation found convincing evidence that PSC frequently recurs in the hepatic allograft using strict inclusion and exclusion criteria. Expand
Gallbladder disease in patients with primary sclerosing cholangitis.
TLDR
It is indicated that gallbladder abnormalities are common among patients with primary sclerosing cholangitis, and sonography is the most useful technique for evaluating these conditions. Expand
Morphologic features of chronic hepatitis associated with primary sclerosing cholangitis and chronic ulcerative colitis
TLDR
The recognition of strikingly similar morphologic features in many liver specimens from patients with either PSC or CUC or both suggests that the causes of these conditions are closely related. Expand
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