• Publications
  • Influence
Fucose: biosynthesis and biological function in mammals.
This review focuses on the biological functions of mammalian fucosylated glycans and the biosynthetic processes leading to formation of the fucOSylated glycan precursor GDP-fucose, a deoxyhexose that is present in a wide variety of organisms. Expand
A role for leukocyte-endothelial adhesion mechanisms in epilepsy
Leukocyte-endothelial interaction is suggested as a potential target for the prevention and treatment of epilepsy by showing that seizures induce elevated expression of vascular cell adhesion molecules and enhanced leukocytes rolling and arrest in brain vessels mediated by the leukocyte mucin P-selectin glycoprotein ligand-1. Expand
Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with
Analysis of two new DNA segments physically linked to, and cross-hybridize with, the H locus indicate that Sec2 corresponds to the human Secretor blood group locus (FUT2) and indicate that homozygosity for a common nonsense allele is responsible for the nonsecretor phenotype in many non-secretor individuals. Expand
The α(1,3)Fucosyltransferase Fuc-TVII Controls Leukocyte Trafficking through an Essential Role in L-, E-, and P-selectin Ligand Biosynthesis
It is demonstrated here that mice deficient in alpha(1,3) fucosyltransferase Fuc-TVII exhibit a leukocyte adhesion deficiency characterized by absent leukocytes E- and P-selectin ligand activity and deficient HEV L- selectin ligands activity. Expand
Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense.
Rac2-deficient mice were created to define the physiological requirement for two near-identical Rac proteins in hematopoietic cells, and showed significant defects in chemotaxis, in shear-dependent L-selectin-mediated capture on the endothelial substrate Glycam-1, and in both F-actin generation and p38 and p42/p44 MAP kinase activation induced by chemoattractants. Expand
Core 2 oligosaccharide biosynthesis distinguishes between selectin ligands essential for leukocyte homing and inflammation.
It is indicated that core 2 oligosaccharide biosynthesis segregates the physiologic roles of selectins and reveal a function for the C2 GlcNAcT in myeloid homeostasis and inflammation. Expand
A genetic approach to Mammalian glycan function.
  • J. Lowe, J. Marth
  • Biology, Medicine
  • Annual review of biochemistry
  • 28 November 2003
The study of glycans has entered an era of renaissance that coincides with the acquisition of complete genome sequences for multiple organisms and an increased focus upon how posttranslational modifications to protein contribute to the complexity of events mediating normal and disease physiology. Expand
A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase.
Results indicate that this cDNA is the product of the human Lewis blood group locus, provide genetic confirmation of the hypothesis that this enzyme can catalyze two distinct transglycosylation reactions, and outline an approach to the isolation of other sequences that determine expression of developmentally regulated oligosaccharide antigens. Expand
Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency.
The syndrome of Rac2 dysfunction represents a human condition associated with mutation of a Rho GTPase and is another example of human disease associated with abnormalities of small G protein signaling pathways. Expand
Role of glycosylation in development.
A review of recent studies analyzing function of a variety of glycoconjugates, focusing on lessons learned from human disease and genetic studies in mice, Drosophila melanogaster, and Caenorhabditis elegans, suggests that O-fucose, O-mannose, N-glycans, mucin-type O-gly cans and proteoglycans are likely to play important roles in developmental processes. Expand