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- Publications
- Influence
Synthesis and some pharmacological properties of [4-threonine, 7-glycine]oxytocin, [1-(L-2-hydroxy-3-mercaptopropanoic acid), 4-threonine, 7-glycine]oxytocin (hydroxy[Thr4, Gly7]oxytocin), and…
- J. Lowbridge, M. Manning, J. Haldar, W. H. Sawyer
- Chemistry, Medicine
- Journal of medicinal chemistry
- 1977
[4-Threonine, 7-glycine]oxytocin and [1-(L-2-hydroxy-3-mercaptopropanoic acid), 4-threonine, 7-glycine]oxytocin (hydroxy[Thr4, Gly7]oxytocin) were synthesized by a combination of solid-phase and… Expand
[1-(beta-mercapto-beta,beta-cyclopentamethylenepropionic acid),4-valine,-8-D-arginine]vasopressin, a potent and selective inhibitor of the vasopressor response to arginine-vasopressin.
- J. Lowbridge, M. Manning, J. Haldar, W. H. Sawyer
- Chemistry, Medicine
- Journal of medicinal chemistry
- 1 March 1978
As part of a program in which we are attempting the design and synthesis of an antagonist of the antidiuretic response to arginine-vasopressin (AVP)… Expand
The design of effective in vivo antagonists of rat uterus and milk ejection responses to oxytocin.
- W. H. Sawyer, J. Haldar, +5 authors M. Manning
- Biology, Medicine
- Endocrinology
- 1980
Several new synthetic analogs of the oxytocin antagonist [1-deaminopenicillamine]oxytocin have been prepared and tested for their abilities to inhibit responses to oxytocin by the isolated rat uterus… Expand
[1-deaminopenicillamine,4-valine]-8-D-arginine-vasopressin, a highly potent inhibitor of the vasopressor response to arginine-vasopressin.
- M. Manning, J. Lowbridge, C. Stier, J. Haldar, W. H. Sawyer
- Chemistry, Medicine
- Journal of medicinal chemistry
- 1 September 1977
In attempting to design an antagonist of the antidiuretic response to arginine-vasopressin (AVP) [1-deaminopenicillamine,4-valine,8-D-arginine]vasopressin (dPVDAVP) was synthesized by the solid-phase… Expand
Synthetic antagonists of in vivo responses by the rat uterus to oxytocin.
- J. Lowbridge, M. Manning, J. Seto, J. Haldar, W. H. Sawyer
- Chemistry, Medicine
- Journal of medicinal chemistry
- 1 May 1979
As part of a program in which we are attempting to synthesize in vivo antagonists of oxytocin, the following four analogues were synthesized and tested for antagonistic activities in rat uterus and… Expand
[1-Deaminopenicillamine,4-threonine]oxytocin, a potent inhibitor of oxytocin.
- M. Manning, J. Lowbridge, J. Seto, J. Haldar, W. H. Sawyer
- Chemistry, Medicine
- Journal of medicinal chemistry
- 1 February 1978
[1-Deaminopenicillamine,4-threonine]oxytocin was prepared in duplicate from S-benzyl-3-mercapto-3,3-dimethylpropanoyl-Tyr(Bzl)-Ile-Thr(Bzl)-Asn-Cys(Bzl)-Pro-Leu-Gly-NH2 (I) by removal of the… Expand
Design of neurohypophyseal peptides that exhibit selective agonistic and antagonistic properties.
- M. Manning, J. Lowbridge, J. Haldar, W. H. Sawyer
- Chemistry, Medicine
- Federation proceedings
- 1 May 1977
Within the spectrum of the characteristic pharmacological activities (oxytocic (O), milk-ejecting (ME), antidiuretic (A), pressor (P) associated with the known natural and synthetic analogs of… Expand
[1-(L-2-hydroxy-3-mercaptopropanoic acid)] analogues of arginine-vasopressin, [8-D-arginine]vasopressin, and [4-valine,8-D-arginine]vasopressin.
- J. Lowbridge, M. Manning, J. Haldar, W. Sawyer
- Chemistry, Medicine
- Journal of medicinal chemistry
- 1 September 1977
[1-(L-2-Hdroxy-3-mercaptopropanic acid)]arginine-vasopressin (hydroxy-AVP), [1-(L-2-hydroxy-3-mercaptopropanoic acid),8-D-arginine]vasopressin (hydroxy-DAVP), and [1-(L-2-hydroxy-3-mercaptopropanoic… Expand
Studies on the extended active site of papain.
- J. Lowbridge, J. Fruton
- Chemistry, Medicine
- The Journal of biological chemistry
- 10 November 1974
Abstract A series of papain substrates of the type A-Val-Glu-Leu-Gly has been synthesized, in which the Glu-Leu bond is the only one cleaved by the enzyme under the conditions of these studies, and… Expand
The molecular conformation of cyclotri-β-alanyl
- D. White, C. Morrow, P. Cox, C. N. Drey, J. Lowbridge
- Chemistry
- 1975
The title compound has been studied by molecular mechanics calculations. There is no single, well defined global minimum energy conformation and the low energy conformations are unrelated to the… Expand