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Dlx5 regulates regional development of the branchial arches and sensory capsules.
TLDR
The distinct focal defects within the branchial arches of the Dl1, Dlx2 and DlX5 mutants, along with the nested expression of their RNAs, support a model in which these genes have both redundant and unique functions in the regulation of regional patterning of the craniofacial ectomesenchyme. Expand
A Subpopulation of Olfactory Bulb GABAergic Interneurons Is Derived from Emx1- and Dlx5/6-Expressing Progenitors
TLDR
The results suggest that some OB interneurons are derived from progenitors outside the LGE and that precursors expressing what has classically been considered a pallial transcription factor generate GABAergic interneeurons. Expand
Short- and Long-Range Attraction of Cortical GABAergic Interneurons by Neuregulin-1
TLDR
Observations provide evidence that Neuregulin-1 and its ErbB4 receptor directly control neuronal migration in the nervous system. Expand
Regional Distribution of Cortical Interneurons and Development of Inhibitory Tone Are Regulated by Cxcl12/Cxcr4 Signaling
TLDR
It is shown that a chemokine, Cxcl12, is an attractant for interneurons during the stage of stream formation and tangential migration and the timing of exit from the migratory streams accompanies loss of responsiveness to CxCl12 as an attractants. Expand
CXCR4 and CXCR7 Have Distinct Functions in Regulating Interneuron Migration
TLDR
It is suggested that CXCR4 and CX CR7 have distinct roles and signal transduction in regulating interneuron movement and laminar positioning. Expand
Distinct molecular pathways for development of telencephalic interneuron subtypes revealed through analysis of Lhx6 mutants
TLDR
Evidence is provided that Lhx6 mediates these effects through promoting expression of receptors that regulate interneuron migration, and through promoting the expression of transcription factors either known (Arx) or implicated (bMaf, Cux2, and NPAS1) in controllingInterneuron development. Expand
DLX5 Regulates Development of Peripheral and Central Components of the Olfactory System
TLDR
The DLX5−/− mutation has a cell-autonomous effect on the ability of neural progenitors to produce olfactory bulb local circuit neurons, with granule cells more severely affected than periglomerular cells. Expand
FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development
TLDR
FGF15 and FGF8 have distinct signaling properties, and opposite effects on neocortical patterning and differentiation; FGF15 promotes CoupTF1 expression, represses proliferation and promotes neural differentiation. Expand
Distinct cis-Regulatory Elements from the Dlx1/Dlx2 Locus Mark Different Progenitor Cell Populations in the Ganglionic Eminences and Different Subtypes of Adult Cortical Interneurons
TLDR
Data suggest that interneuron subtypes use distinct combinations of Dlx1/Dlx2 enhancers from the time they are specified through adulthood, and evidence that the dorsomedial and ventral MGE are distinct sources of tangentially migrating neurons during midgestation is provided. Expand
Lhx6 and Lhx8 Coordinately Induce Neuronal Expression of Shh that Controls the Generation of Interneuron Progenitors
TLDR
Lhx6 and Lhx8 transcription factor coexpression in early-born MGE neurons is required to induce neuronal Shh expression, which feeds forward to promote the developmental program of the rostrodorsal MGE. Expand
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