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Lack of commensal flora in Helicobacter pylori-infected INS-GAS mice reduces gastritis and delays intraepithelial neoplasia.
BACKGROUND & AIMS Transgenic FVB/N insulin-gastrin (INS-GAS) mice have high circulating gastrin levels, and develop spontaneous atrophic gastritis and gastrointestinal intraepithelial neoplasia (GIN)Expand
Restrained whole body plethysmography for measure of strain-specific and allergen-induced airway responsiveness in conscious mice.
The mouse is the most extensively studied animal species in respiratory research, yet the technologies available to assess airway function in conscious mice are not universally accepted. WeExpand
Gastric colonisation with a restricted commensal microbiota replicates the promotion of neoplastic lesions by diverse intestinal microbiota in the Helicobacter pylori INS-GAS mouse model of gastric
Objectives Gastric colonisation with intestinal flora (IF) has been shown to promote Helicobacter pylori (Hp)-associated gastric cancer. However, it is unknown if the mechanism involves colonisationExpand
Association of expiratory airway dysfunction with marked obesity in healthy adult dogs.
OBJECTIVE To evaluate the effects of obesity on pulmonary function in healthy adult dogs. ANIMALS 36 Retrievers without cardiopulmonary disease. PROCEDURES Dogs were assigned to 1 of 3 groups onExpand
Validation of a Behavioral Ethogram for Assessing Postoperative Pain in Guinea Pigs (Cavia porcellus).
Although guinea pigs (Cavia porcellus) have been used in research for more than a century and remain the most prevalent USDA-covered species, little has been elucidated regarding the recognition ofExpand
Helminth co-infection in Helicobacter pylori infected INS-GAS mice attenuates gastric premalignant lesions of epithelial dysplasia and glandular atrophy and preserves colonization resistance of the
Higher prevalence of helminth infections in Helicobacter pylori infected children was suggested to potentially lower the life-time risk for gastric adenocarcinoma. In rodent models, helminthExpand
Analgesics promote welfare and sustain tumour growth in orthotopic 4T1 and B16 mouse cancer models
Murine orthotopic cancer models often require surgery, potentially causing pain or distress. However, analgesics are often withheld because they may alter tumour development. Two orthotopicallyExpand
A Review of Pain Assessment Methods in Laboratory Rodents.
Ensuring that laboratory rodent pain is well managed underpins the ethical acceptability of working with these animals in research. Appropriate treatment of pain in laboratory rodents requiresExpand
Canine awake head-out plethysmography (HOP): Characterization of external resistive loading and spontaneous laryngeal paralysis
We applied a novel head-out plethysmographic (HOP) method to study awake canine responses to external resistive loading and natural laryngeal paralysis. Measurements of inspiratory and expiratoryExpand
Association of expiratory airway dysfunction with marked obesity in healthy adult dogs.
Objective—To evaluate the effects of obesity on pulmonary function in healthy adult dogs. Animals—36 Retrievers without cardiopulmonary disease. Procedures—Dogs were assigned to 1 of 3 groups on theExpand
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