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Interleukin-10-deficient mice develop chronic enterocolitis
TLDR
The results indicate that the bowel inflammation in the mutants originates from uncontrolled immune responses stimulated by enteric antigens and that IL-10 is an essential immunoregulator in the intestinal tract. Expand
The casein kinase 1 family: participation in multiple cellular processes in eukaryotes.
TLDR
This review will summarize the current knowledge about the function and regulation of mammalian CK1 isoforms. Expand
Immunodeficiency and Chronic Myelogenous Leukemia-like Syndrome in Mice with a Targeted Mutation of the ICSBP Gene
TLDR
A novel role for ICSBP is suggested in regulating the proliferation and differentiation of hematopoietic progenitor cells in mice with a null mutation of ICS BP. Expand
Essential Role of Ubiquitin-Specific Protease 8 for Receptor Tyrosine Kinase Stability and Endocytic Trafficking In Vivo
TLDR
It is shown that lack of UBPy results in embryonic lethality, whereas its conditional inactivation in adults causes fatal liver failure, unveiling a central and nonredundant role in growth regulation, endosomal sorting, and the control of RTKs in vivo. Expand
Generalized autoimmune disease in interleukin‐2‐deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells
TLDR
It is suggested that an essential role of IL‐2 in vivo, which is not compensated by other cytokines, is the maintenance of self tolerance. Expand
Altered development and cytokine responses of myeloid progenitors in the absence of transcription factor, interferon consensus sequence binding protein.
TLDR
ICSBP(-/-) myeloid progenitor cells share several abnormal features with CML progenitors, suggesting that the distal parts of signaling pathways of these two disorders are overlapping. Expand
Critical role for beta7 integrins in formation of the gut-associated lymphoid tissue.
TLDR
It is reported that, in mice deficient for the beta7 integrin subfamily of adhesion molecules, the formation of the GALT is severely impaired, probably due to a failure of beta7-/- lymphocytes to arrest and adhere to the vasculature at the site of transmigration into the Galt. Expand
Antiviral immune responses of lymphocytic choriomeningitis virus-infected mice lacking CD8+ T lymphocytes because of disruption of the beta 2-microglobulin gene
TLDR
Examining LCM virus-specific immune responses in mice devoid of CD8+ T lymphocytes as a result of disruption of the Lyt-2-encoding gene provides clues that may help to understand the mode of action of the CD8- T cells in cell-mediated antiviral immunity. Expand
AML1-ETO Inhibits Maturation of Multiple Lymphohematopoietic Lineages and Induces Myeloblast Transformation in Synergy with ICSBP Deficiency
TLDR
It is demonstrated that AML1-ETO synergizes with an ICSBP deficiency to induce myeloblastic transformation in the BM, reminiscent of AML. Expand
A transgenic mouse model for the ductal carcinoma in situ (DCIS) of the mammary gland
TLDR
These transgenic lines are proposed as an experimental model to study the underlying molecular events leading to DCIS and its progression to invasive disease and exhibit distinct architectural and cytological features which closely resemble those commonly present in humans. Expand
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