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Say no to DMSO: dimethylsulfoxide inactivates cisplatin, carboplatin, and other platinum complexes.
TLDR
It is found that DMSO reacted with the platinum complexes, inhibited their cytotoxicity and their ability to initiate cell death, rendering a substantial portion of the literature on cisplatin uninterpretable. Expand
Meropenem inhibits D,D‐carboxypeptidase activity in Mycobacterium tuberculosis
TLDR
The results suggest that the rapid lysis of meropenem‐treated cells is the result of synergistically inhibiting the transpeptidases that introduce 3,3‐cross‐links while simultaneously limiting the pool of available substrates available for cross‐linking. Expand
Chrysophaentins A-H, antibacterial bisdiarylbutene macrocycles that inhibit the bacterial cell division protein FtsZ.
TLDR
Eight new antimicrobial natural products named chrysophaentins A-H belonging to a new structural class have been isolated from the marine chrysophyte alga Chrysophaeum taylori and are characterized by the presence of two polyhalogenated, polyoxygenated omega,omega'-diarylbutene units connected by two ether bonds to form the suite of macrocyclic natural products. Expand
Structural basis of G protein-coupled receptor-G protein interactions.
TLDR
A comprehensive GPCR-G protein alpha subunit (Galpha) chemical cross-linking strategy is applied to map a receptor-Galpha interface, both before and after agonist-induced receptor activation, to draw conclusions regarding the basic architecture of the M3R- Galpha interface and the nature of the conformational changes following receptor activation. Expand
Celebesides A-C and theopapuamides B-D, depsipeptides from an Indonesian sponge that inhibit HIV-1 entry.
TLDR
Six new depsipeptides belonging to two different structural classes, termed celebesides A-C and theopapuamides B-D, have been isolated from the marine sponge Siliquariaspongia mirabilis using extensive 2D NMR and ESI-MS/MS techniques. Expand
Mutremdamide A and koshikamides C-H, peptide inhibitors of HIV-1 entry from different Theonella species.
TLDR
The combination of mutremdamide A, koshikamides, and theonellamides appears to define a new Theonella chemotype that can be found in deeper waters. Expand
Cholest‐5‐ene‐3β,26‐diol: Synthesis and biomedical use of a deuterated compound
To further studies of the metabolism of 26-hydroxycholesterol in fetal and neonatal life, a deuterated compound was prepared from kryptogenin by Clemmensen reduction. The spectra of the deuteratedExpand
Structural Basis of HIV-1 Neutralization by Affinity Matured Fabs Directed against the Internal Trimeric Coiled-Coil of gp41
TLDR
Crystal structures of the N-HR mimetic 5-Helix with two Fabs suggest that both neutralization properties and affinity for the target can be attributed, at least in part, to the differences in the interactions of the CDR-H2 loops with the antigen. Expand
Solid-phase synthesis of thermolytic DNA oligonucleotides functionalized with a single 4-hydroxy-1-butyl or 4-phosphato-/thiophosphato-1-butyl thiophosphate protecting group.
TLDR
Several thermolytic CpG-containing DNA oligonucleotides analogous to 1 have been synthesized to serve as potential immunotherapeutic olig onucleotide prodrug formulations for the treatment of infectious diseases in animal models, validating the function of these diastereomeric oligon nucleotides as prodrugs in vitro. Expand
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