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The behavioral syndrome caused by 3,3'-iminodipropionitrile and related nitriles in the rat is associated with degeneration of the vestibular sensory hair cells.
Animals exposed to 3,3'-iminodipropionitrile (IDPN) or to several similar nitriles develop a permanent syndrome of behavioral abnormalities. The present work addressed the hypothesis that thisExpand
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Syntaxin 1A and 1B display distinct distribution patterns in the rat peripheral nervous system
Syntaxin 1 has been shown to play an outstanding role in synaptic vesicle exocytosis. Two isoforms of this protein are expressed in neurons, syntaxin 1A and 1B. However, the physiologicalExpand
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Differential effects of trans‐crotononitrile and 3‐acetylpyridine on inferior olive integrity and behavioural performance in the rat
The inferior olive climbing fibre projection is key to cerebellar contributions to motor control. Here we present evidence for a novel tool, trans‐crotononitrile (TCN), to selectively inactivate theExpand
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Olfactory toxicity of beta,beta'-iminodipropionitrile in the rat.
Following a pilot study which revealed olfactory epithelial degeneration induced by beta,beta'-iminodipropionitrile (IDPN), dose-response and time-course analyses were undertaken to furtherExpand
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Age-related effects of aluminum ingestion on brain aluminum accumulation and behavior in rats.
Both aluminum and aging have been associated with neurobehavioral changes in mammals. This study assessed in young (21 day old), adult (8 months), and old rats (16 months) the effects of prolongedExpand
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The targets of acetone cyanohydrin neurotoxicity in the rat are not the ones expected in an animal model of konzo.
Konzo is a neurotoxic motor disease caused by excess consumption of insufficiently processed cassava. Cassava contains the cyanogenic glucoside linamarin, but konzo does not present the knownExpand
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Behavioural disturbances and sensory pathology following allylnitrile exposure in rats
Animals exposed to allylnitrile develop permanent abnormalities in motor behaviour, similar to those caused by 3,3'-iminodipropionitrile (IDPN) and crotononitrile. IDPN and crotononitrile effectsExpand
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Relationship between insult intensity and mode of hair cell loss in the vestibular system of rats exposed to 3,3′‐iminodipropionitrile
A variety of stimuli cause sensory hair cell loss in the mammalian inner ear. This loss occurs by several differing processes, the significance of which remains undetermined. This study examines theExpand
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Comparison of cis- and trans-crotononitrile effects in the rat reveals specificity in the neurotoxic properties of nitrile isomers.
The neurotoxic compound crotononitrile has two isomeric forms, cis and trans. We compared the effects of these two isomers isolated by distillation from the commercially available mixture. Adult maleExpand
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Allylnitrile metabolism by CYP2E1 and other CYPs leads to distinct lethal and vestibulotoxic effects in the mouse.
This study addressed the hypothesis that the vestibular or lethal toxicities of allylnitrile depend on CYP2E1-mediated bioactivation. Wild-type (129S1) and CYP2E1-null male mice were exposed toExpand
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