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Retrograde Viral Delivery of IGF-1 Prolongs Survival in a Mouse ALS Model
TLDR
It is reported that insulin-like growth factor 1 prolongs life and delays disease progression, even when delivered at the time of overt disease symptoms. Expand
Tumor Necrosis Factor Alpha: A Link between Neuroinflammation and Excitotoxicity
TLDR
This review summarizes the current knowledge of the cellular and molecular mechanisms by which TNF-α links the neuroinflammatory and excitotoxic processes that occur in several neurodegenerative diseases, but with a special emphasis on amyotrophic lateral sclerosis (ALS). Expand
Human Embryonic Germ Cell Derivatives Facilitate Motor Recovery of Rats with Diffuse Motor Neuron Injury
TLDR
It is concluded that cells derived from human pluripotent stem cells have the capacity to restore neurologic function in animals with diffuse motor neuron disease via enhancement of host neuron survival and function. Expand
Neural stem cells protect against glutamate-induced excitotoxicity and promote survival of injured motor neurons through the secretion of neurotrophic factors
TLDR
The neuroprotective potential of NSCs was further confirmed in vivo by their ability to protect against motor neuron cell death and it was shown that N SCs can protect spinal cord cultures from experimentally induced excitotoxic damage. Expand
Multimodal Actions of Neural Stem Cells in a Mouse Model of ALS: A Meta-Analysis
TLDR
It is proposed that transplanted NSCs (both mouse and human) can slow both the onset and the progression of clinical signs and prolong survival in ALS mice, particularly if regions sustaining vital functions such as respiration are rendered chimeric. Expand
Vascular endothelial growth factor protects spinal cord motoneurons against glutamate‐induced excitotoxicity via phosphatidylinositol 3‐kinase
TLDR
It is indicated that VEGF has neuroprotective effects in rat spinal cord against chronic glutamate excitotoxicity by activating the PI3‐K/Akt signal transduction pathway and the hypothesis of the potential therapeutic effects of VEGf in the prevention of motoneuron degeneration in human ALS is reinforced. Expand
Degeneration of respiratory motor neurons in the SOD1 G93A transgenic rat model of ALS
TLDR
Data suggest that respiratory motor neuron loss results in significant electrophysiologic changes and diaphragmatic atrophy, which may play a significant role resulting in death of these animals. Expand
Cell stress induces TDP-43 pathological changes associated with ERK1/2 dysfunction: implications in ALS
TLDR
It is demonstrated that cellular stressors are key factors in neurodegeneration associated with TDP-43 and the identity of ERK1/2 as novel players in the pathogenesis of ALS is disclosed. Expand
Glial restricted precursors protect against chronic glutamate neurotoxicity of motor neurons in vitro
TLDR
It is shown that glial restricted precursors and GRIP‐derived astrocytes predominantly express glutamate transporters GLAST and GLT1 and that these cells may potentially play a role in cell‐based neuroprotection from glutamate excitotoxicity. Expand
Opposing Effects of Excitatory Amino Acids on Chick Embryo Spinal Cord Motoneurons: Excitotoxic Degeneration or Prevention of Programmed Cell Death
TLDR
It is indicated for the first time that early activation of NMDA receptors in developing avian MNs in vivo has a trophic, survival-promoting effect, inhibiting PCD by a target-independent mechanism that involves NMDA receptor downregulation. Expand
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