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LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1
The results show that LKB1 functions as a master upstream protein kinase, regulating AMPK‐related kinases as well as AMPK, and may mediate the physiological effects of L KB1, including its tumour suppressor function.
Phosphorylation of the Protein Kinase Mutated in Peutz-Jeghers Cancer Syndrome, LKB1/STK11, at Ser431 by p90RSK and cAMP-dependent Protein Kinase, but Not Its Farnesylation at Cys433, Is Essential…
It is demonstrated that stimulation of Rat-2 or embryonic stem cells with activators of ERK1/2 or of cAMP-dependent protein kinase induced phosphorylation of endogenously expressed LKB1 at Ser431, and that full-length L KB1 expressed in 293 cells was prenylated by addition of a farnesyl group to Cys433.
The insulin signalling pathway
Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155.
Ser(155) is identified as a third phosphorylation site on BAD and is the only residue in BAD that becomes phosphorylated when cells are exposed to cAMP-elevating agents, and prevents it from binding to Bcl-X(L) and promotes its interaction with 14-3-3 proteins.
Identification of the sucrose non‐fermenting related kinase SNRK, as a novel LKB1 substrate
High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site
The 2.0 Å crystal structure of the PDK1 kinase domain in complex with ATP defines the hydrophobic pocket termed the ‘PIF‐pocket’, which plays a key role in mediating the interaction and phosphorylation of certain substrates such as S6K1.
Role of Semicarbazide-sensitive Amine Oxidase on Glucose Transport and GLUT4 Recruitment to the Cell Surface in Adipose Cells*
It is proposed that SSAO activity might contribute through hydrogen peroxide production to the in vivo regulation of GLUT4 trafficking in adipose cells.
Dopaminergic and Glutamatergic Signaling Crosstalk in Huntington's Disease Neurodegeneration: The Role of p25/Cyclin-Dependent Kinase 5
- P. Paoletti, I. Vila, M. Rifé, J. Lizcano, J. Alberch, S. Ginés
- Biology, ChemistryThe Journal of Neuroscience
- 1 October 2008
It is demonstrated in knock-in HD striatal cells that mutant huntingtin enhances dopamine-mediated striatal cell death via dopamine D1 receptors, and p25/Cdk5 is identified as an important mediator of dopamine and glutamate neurotoxicity associated to HD.
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
A set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes are presented.
Purification and characterization of membrane-bound semicarbazide-sensitive amine oxidase (SSAO) from bovine lung.
The bovine lung enzyme was relatively insensitive to inhibition by cyanide, copper-chelating agents and amiloride, and narrower than reported for soluble SSAO.